Iron chelation new therapeutic approach for hepatocellular carcinoma

[ironjustice@aol.com]

Deferoxamine enhances anti-proliferative effect of interferon-gamma
against hepatocellular carcinoma cells.
Okada T, Sawada T, Kubota K
Cancer Lett. 2006 Jul 10;
The aims of this study were to investigate whether iron chelation,
blocking of the human insulin-like growth factor-1 receptor (hIGF1R),
or both could upregulate IFN-gammaR2 and enhance the anti-proliferative
effect of IFN-gamma.
METHODS: Two HCC cell lines, HuH7 and SNU449, were treated with the
iron-chelating agent deferoxamine (DFO), IFN-gamma, and/or anti-hIGF1R
blocking antibody.
CONCLUSION: The present results indicate that IFN-gamma reinforced by
iron modulation could be a promising new therapeutic approach for HCC..


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