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Rex
medicine forum beginner
Joined: 16 Jun 2006
Posts: 2
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 Posted: Fri Jun 16, 2006 6:48 pm Post subject:
Wet AMD Clinical Trial
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Hi all,
I'm a new member here and I would like to inform those of you who have
wet AMD, or know someone who does, that a new clinical trial is
starting soon to test Evizon, a new treatment now in stage II and III
clinical trials. The drug, put out by Genaera Corp., looks very
promising especially since it is administered intravenously rather than
with injections directly into the affected eye as with other drugs such
as Avastin and Lucentis. Unlike the other treatments, Evizon also
treats both eyes at the same time and its safety has been demonstrated
in previous trials. The FDA has granted fast track status for Evizon
and even selected it for a special FDA monitoring program for new
promising treatments. The new trial, called 212, is recruiting right
now and I believe patients are paid $75 per visit or treatment. More
information can be attained at Genaera's website: www.genaera.com or by
calling Genaera's Wayne Yarnell at 610-941-5655 or Linda Solomon
(returns on June 19th) at 610-941-4020.
By the way, I am not an employee of Genaera nor have I been engaged by
Genaera.
Good luck to all. |
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Anon E. Muss
medicine forum Guru Wannabe
Joined: 22 May 2006
Posts: 136
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| Posted: Fri Jun 16, 2006 7:56 pm Post subject:
Re: Wet AMD Clinical Trial
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On 16 Jun 2006 11:48:48 -0700, "Rex" <netwell.inc@verizon.net> wrote:
| Quote: | I'm a new member here and I would like to inform those of you who have
wet AMD, or know someone who does, that a new clinical trial is
starting soon to test Evizon, a new treatment now in stage II and III
clinical trials. The drug, put out by Genaera Corp., looks very
promising especially since it is administered intravenously rather than
with injections directly into the affected eye as with other drugs such
as Avastin and Lucentis.
|
How does the fact that it is intravenously administered make it look
more *promising* than if it were administered via intraocular
injection?
[snip] |
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Rex
medicine forum beginner
Joined: 16 Jun 2006
Posts: 2
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| Posted: Sat Jun 17, 2006 8:25 pm Post subject:
Re: Wet AMD Clinical Trial
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Anon E. Muss wrote:
| Quote: | On 16 Jun 2006 11:48:48 -0700, "Rex" <netwell.inc@verizon.net> wrote:
I'm a new member here and I would like to inform those of you who have
wet AMD, or know someone who does, that a new clinical trial is
starting soon to test Evizon, a new treatment now in stage II and III
clinical trials. The drug, put out by Genaera Corp., looks very
promising especially since it is administered intravenously rather than
with injections directly into the affected eye as with other drugs such
as Avastin and Lucentis.
How does the fact that it is intravenously administered make it look
more *promising* than if it were administered via intraocular
injection?
[snip]
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Good question, Anon. The answer lies in the fact that there are quite
a few safety issues associated with injections directly into the eye
ball. Evizon is not administered via intravitreal injection but rather
intravenously, which is much safer and a lot more comfortable. Another
safety issue associated with needles in the eye is that many people who
are afraid of normal injections are terrified at the prospect of having
to undergo an injection into the eyeball itself. Since the population
of wet AMD patients tend to be older, the stress associated with
intravitreal injections could have very serious consequences especially
if the patient has any health issues that could be aggravated by that
stress. I know that even when my eye doctor wants to put eye drops in
my eye, I can feel my blood pressure sky rocket. So my answer to you
is that aside from the efficacy of Evizon which is good and has
advantages that other treatments don't have, it has been demonstrated
to be safer than other treatments and that safety profile, in and of
itself, makes Evizon a very promising treatment for Wet AMD. Thanks
for the question.
Rex |
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Anon E. Moose
medicine forum beginner
Joined: 17 Jun 2006
Posts: 4
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| Posted: Sat Jun 17, 2006 10:25 pm Post subject:
Re: Wet AMD Clinical Trial
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On 17 Jun 2006 13:25:42 -0700, "Rex" <netwell.inc@verizon.net> wrote:
| Quote: | Anon E. Muss wrote:
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[snip]
| Quote: | How does the fact that it is intravenously administered make it look
more *promising* than if it were administered via intraocular
injection?
[snip]
Good question, Anon. The answer lies in the fact that there are quite
a few safety issues associated with injections directly into the eye
ball. Evizon is not administered via intravitreal injection but rather
intravenously, which is much safer and a lot more comfortable. Another
safety issue associated with needles in the eye is that many people who
are afraid of normal injections are terrified at the prospect of having
to undergo an injection into the eyeball itself. Since the population
of wet AMD patients tend to be older, the stress associated with
intravitreal injections could have very serious consequences especially
if the patient has any health issues that could be aggravated by that
stress. I know that even when my eye doctor wants to put eye drops in
my eye, I can feel my blood pressure sky rocket.
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Relax... It's just eyedrops... :)
Here's a typical example and lines I use:
*Female patient freaking out from eyedrops*
Me: Do you have any children?
Patient: Yes. 3.
Me: So you've gone through childbirth and you are stressing
out with me putting a few eyedrops in your eyes  ???
Many times that gets them to relax a little. I have to think up a
good on to use on my male patients (besides driving a knuckle into
their head :^O ).
Same thing goes when I do tonometry, scleral indentation, gonioscopy,
contact lens application/removal, lacrimal dilation/probing, foreign
body removal, etc.
| Quote: | So my answer to you is that aside from the efficacy of Evizon which is
good and hasadvantages that other treatments don't have, it has been
demonstrated to be safer than other treatments and that safety
profile, in and of itself, makes Evizon a very promising treatment for
Wet AMD. Thanks for the question.
|
I guess we are just talking semantics.
I understood how many patients would prefer an IV injection versus an
intraocular, I just don't/didn't understand how that, in and of
itself, makes it more **promising**.
Promising, to me, is based on its potential or real efficacy, not the
method of delivery.
But I get what you were getting at now. |
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