Regression of Existing Atherosclerotic Lesions / taurine

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Effect of a Taurine Treatment on the Regression of Existing
Atherosclerotic Lesions in Rabbits Fed on a High-cholesterol Diet

Jale Balkan,1,† Serdar Öztezcan,1 Aydan Hatipoglu,2 Ugur Çevikbas,3
Gülçin Aykaç-toker,1 and Müjdat Uysal1

1Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul
University, 34093 Çapa-Istanbul, Turkey
2Eczacibasi Pharmaceutical Company, Lüleburgaz, Turkey
3Department of Pathology, Istanbul Faculty of Medicine, Istanbul
University, Turkey

We studied whether taurine has any regressive effect on existing
atherosclerotic lesions and lipid peroxidation in rabbits fed on a
high-cholesterol (HC) diet. The cholesterol, triglyceride,
malondialdehyde (MDA) and diene conjugate (DC) levels, as well as the
aortic histopathological findings were examined in rabbits that had
been fed on a cholesterol-containing diet for 8 months [0.5%
cholesterol (w/w) for 3 months and subsequently 0.25% cholesterol (w/w)
for 5 months], and then for a further 4 months on a normal diet with or
without taurine treatment [1% (w/v) in the drinking water]. High levels
of lipid and lipid peroxide induced by the HC diet were observed to
decline in the plasma, liver and aorta of atherosclerotic rabbits, as
well as a slight retardation in aortic atherosclerotic lesions during
the regression period. Although no significant differences in the lipid
and lipid peroxide levels in the plasma and aorta were found between
the regressed groups with or without the taurine treatment, the extent
of atherosclerotic lesions in the aorta was less in the taurine-treated
regressed group than in the non-treated regressed group. However, the
liver MDA and DC levels were lower in the regressed rabbits with the
taurine treatment in the non-treated group. These results indicate that
the taurine treatment may accelerate the regression of
cholesterol-induced atherosclerotic lesions in rabbits without having
any effect on the plasma and aorta lipid and lipid peroxide levels.

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Alf Christophersen · medicine forum Guru Joined: 01 May 2005 Posts: 738

On 3 May 2005 10:55:50 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:

montygram · medicine forum Guru Joined: 30 Apr 2005 Posts: 825

What Alf and others simply refuse to see is that you can eat a diet
that is nearly devoid of lipid peroxidation, and so with any kind of
reasonable diet, you won't need extra taurine. They are hooked on the
idea that polyunsaturates, which are the worst offenders in terms of
lipid peroxidation (no debate on that point) are "essential," even
though this claim is based on one flawed experiment on rats from 1930
(Biurr & Burr) - the rats were not given vitamins because all the
vitamins were not known at the time. My grandparents never eat omega 3
PUFA foods, and never have, yet they are in fairly good shape (early
90s and mid 80s). I have avoided polyunsaturates for over 3 years,
only getting tiny amounts (that you get from coconut oil or butter, for
example). I am in much better shape physically then I was back then,
and I almost died because I ate so much anti-nutritive food (high
fiber, lots of legumes, which are high in lectins, etc.) and lost the
ability to digest food. I now take stomach acid and pepsin supplements
with each meal, which "cured" me.

Here's a report I read just a few minutes ago that makes this point,
and it's the same point with all these supplements - just avoid
unsaturated fats and you'll be doing the single best thing (in terms of
diet):

Food Fried In Vegetable Oil May Contain Toxic Compound

MINNEAPOLIS / ST. PAUL -- University of Minnesota researchers A. Saari
Csallany, a professor of food chemistry and nutritional biochemistry,
and graduate student Christine Seppanen have shown that when highly
unsaturated vegetable oils are heated at frying temperature (365 F) for
extended periods--or even for half an hour--a highly toxic compound,
HNE (4-hydroxy-trans-2-nonenal) forms in the oil.

Previously, vegetable oils such as soybean, sunflower and corn were
regarded as heart-healthy because of their high levels of linoleic
acid, a polyunsaturated fatty acid. HNE is incorporated into fried food
in the same concentration as it forms in the heated oil. Also, Csallany
and her colleagues have found three toxic HNE-related compounds (known
as HHE, HOE and HDE) in heated soybean oil. They will present their
work at a poster session from 9 a.m. to 2 p.m. Wednesday, May 4, at the
96th annual meeting of the American Oil Chemists Society in the Salt
Lake City Convention Center.

"HNE is a well known, highly toxic compound that is easily absorbed
from the diet," said Csallany. "The toxicity arises because the
compound is highly reactive with proteins, nucleic acids--DNA and
RNA--and other biomolecules. HNE is formed from the oxidation of
linoleic acid, and reports have related it to several diseases,
including atherosclerosis, stroke, Parkinson's, Alzheimer's,
Huntington's and liver diseases."

Csallany's work underscores the risk of repeated heating, or reusing,
highly unsaturated oils for frying because HNE accumulates with each
heating cycle. In future studies, Csallany and her colleagues plan to
determine how long polyunsaturated oil must be heated at lower
temperatures in order to form HNE and its related compounds. The study
was funded by the University of Minnesota.

Source: sciencedaily.com

MattLB · medicine forum Guru Wannabe Joined: 04 May 2005 Posts: 111

montygram wrote:

Dr. Zarkov · medicine forum beginner Joined: 04 May 2005 Posts: 29

Alf Christophersen wrote:

Robert · medicine forum Guru Joined: 28 Apr 2005 Posts: 1700

"Dr. Zarkov" <Ming@Mongo.com> wrote in message
news:9cSdnUNMJboAseTfRVn-gA@rcn.net...

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Neurotox Res. 2000;2(1):1-15. Related Articles, Links

Taurine inhibition of metal-stimulated catecholamine oxidation.

Dawson R Jr, Baker D, Eppler B, Tang E, Shih D, Hern H, Hu M.

Department of Pharmacodynamics, College of Pharmacy, JHMHC Box 100487,
University of Florida, Gainesville, FL 32610, USA. dawson@cop.ufl.edu

Taurine is an abundant amino acid found in mammalian tissues and it has
been suggested to have cytoprotective functions. The aim of the present
study was to determine if taurine had the potential to reduce oxidative
stress associated with metal-stimulated catecholamine oxidation.
Taurine and structural analogs of taurine were tested for their ability
to inhibit metal-stimulated quinone formation from dopamine or L-dopa.
Oxidative damage to proteins and lipids were also assessed in vitro and
the effects of taurine were determined. Taurine (20 mM) was found to
decrease significantly ferric iron (50-500 microM)- and manganese (10
microM)-stimulated L-dopa or dopamine oxidation. Taurine had no effect
on zinc-induced dopamine oxidation and slightly potentiated copper- and
NaIO(4)-stimulated quinone formation. Ferric iron-stimulated lipid
peroxidation was not affected by taurine (1-20 mM). Protein carbonyl
formation induced by ferric iron (500 microM) and L-dopa (500 microM)
was significantly reduced by 10 mM taurine. The cytotoxicity of L-dopa
(250 microM) and ferric chloride (75 microM) to LLC-PK(1) cells was
attenuated by 10 mM taurine or hypotaurine. Homotaurine alone
stimulated L-dopa oxidation and potentiated the cytotoxic effects of
ferric iron. Homotaurine was found to be cytotoxic when combined with
L-dopa or L-dopa/iron. In contrast, hypotaurine inhibited quinone
formation and protected LLC-PK(1) cells. These studies suggest that
taurine may exhibit cytoprotective effects against the oxidation
products of catecholamines by acting as a scavenger for free radicals
and cytotoxic quinones.

PMID: 15545001 [PubMed]

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Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
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DEAD PEOPLE WALKING
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