ironjustice@aol.com
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Joined: 28 Apr 2005
Posts: 1522
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 Posted: Tue Nov 15, 2005 12:25 am Post subject:
Antioxidants / skin cancer
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J Invest Dermatol. 2005 Oct;125(4):826-32. Related Articles, Links
Comment in:
J Invest Dermatol. 2005 Oct;125(4):xii-xiii.
Ferulic acid stabilizes a solution of vitamins C and E and doubles its
photoprotection of skin.
Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, Selim MA,
Monteiro-Riviere NA, Grichnik JM, Zielinski J, Pinnell SR.
Duke University Medical Center, Durham, North Carolina 27710, USA.
Ferulic acid is a potent ubiquitous plant antioxidant. Its
incorporation into a topical solution of 15%l-ascorbic acid and
1%alpha-tocopherol improved chemical stability of the vitamins (C+E)
and doubled photoprotection to solar-simulated irradiation of skin from
4-fold to approximately 8-fold as measured by both erythema and sunburn
cell formation. Inhibition of apoptosis was associated with reduced
induction of caspase-3 and caspase-7. This antioxidant formulation
efficiently reduced thymine dimer formation. This combination of pure
natural low molecular weight antioxidants provides meaningful
synergistic protection against oxidative stress in skin and should be
useful for protection against photoaging and skin cancer.
PMID: 16185284 [PubMed - indexed for MEDLINE]
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