Protective effect of a new antiviral preparation of phosprenyl in experimental tick-borne encephalitis]

CaliforniaLyme · medicine forum Guru Joined: 28 Apr 2005 Posts: 2066

1: Vopr Virusol. 2000 Jan-Feb;45(1):33-7. Related Articles, Links

[Protective effect of a new antiviral preparation of phosprenyl in
experimental tick-borne encephalitis]

[Article in Russian]

Ozherelkov SV, Timofeev AV, Novikova GP, Deeva AV, Narovlianskii AN,
Sanin AV, Pronin AV.

Antiviral activity of phosprenyl was studied in BALB/c mice infected
with tick-borne encephalitis (TBE) virus. Up to 60% animals infected
with TBE virus survived after 1-3 intramuscular injections of
phosprenyl. The mortality in the untreated group infected with the
virus was 100%. Direct antiviral effect of phosprenyl was studied in
sensitive SPEV cells infected with TBE virus. The titer of the virus
decreased 10-fold in the cells treated with the drug vs. untreated
control cells. Phosprenyl stimulates some interleukins:
gamma-interferon, tumor necrosis factor-alpha, and interleukin-6. The
stimulating effect of the drug manifests in intact animals and in those
infected with TBE virus and treated with phosprenyl. The prospects of
further trials of the drug as a therapeutic and prophylactic agent in
TBE are discussed.

PMID: 10695042 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Google