Oxidative DNA damage / orofacial clefts

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

This might well explain the incidence of .. clefts .. in those with ..
iron overload ..

Eh ..

Przegl Lek. 2004;61(12):1310-3. Related Articles, Links

[Oxidative DNA damage in mothers of children with isolated orofacial
clefts]

[Article in Polish]

Hozyasz KK, Chelchowska M, Ambroszkiewicz J, Gajewska J, Dudkiewicz Z,
Laskowska-Klita T.

Klinika Pediatrii Instytutu Matki i Dziecka. khozyasz@alpha.net.pl

Recently, there is increasing evidence suggesting that oxidative stress
may contribute to birth defects. 8-Hydroxy-2'-deoxyguanosine (8-OHdG)
is considered to be a sensitive biomarker of oxidative DNA damage. It
would seem important to establish whether levels of 8-OHdG and
antioxidants are different in mothers of children with orofacial clefts
comparing to women who gave birth to healthy children. The present
study was carried out to investigate this point. Total plasma
antioxidant status (TAS), serum 8-OHdG, plasma alpha-tocopherol and
retinol were determined in 27 healthy mothers of children with isolated
orofacial clefts (cleft lip - 11, cleft lip and palate - 9, cleft
palate - 7; mean age - 26.6+/-3.5 years; mean time after delivery -
6.5+/-8.4 months) and 14 control mothers of children without birth
defect (mean age - 26.4+/-3.0 years, mean time after delivery -
5.7+/-5.8 months). 8-OHdG concentrations were significantly increased
in mothers of children with clefts compared to controls (median - 4.7
ng/mL; range: 0.5-8.6 ng/mL vs. median 1.9 ng/mL; range: 0.1-3.2 ng/
mL; p<0.001 in Wilcoxon test). TAS (median - 1.03 micromol/L; range
0.87 - 1.26 micromol/L vs. median - 1.13 micromol/L; range: 1.03- 1.26
micromol/L; p<0,05) and alpha-tocopherol level (median - 15.8
micromol/L; range: 11.3-26.8 micromol/L vs. median - 20.6 micromol/L;
range: 13.8-26.5 micromol/L; p<0,05) were significantly reduced in
mothers of affected children. There were no differences in vitamin A
levels between the study group and controls. The ratio of
alpha-tocopherol to plasma total cholesterol was lower in women who
gave birth to children with clefts compared to controls (median - 3.16
micromol/mmol vs. median - 3.7 micromol/ mmol; p>0.05). No correlation
was found between TAS, the vitamins and 8-OHdG. We conclude that
depletion of antioxidant systems as well as increased free radical
generation are likely to be involved in the pathophysiology of
orofacial clefts in humans. The results indicate the necessity of
futher studies to establish whether peri-conceptional antioxidant
supplementation will prevent these serious defects.

PMID: 15850319 [PubMed - in process]

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