Erosive lichen planus of the vulva

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

<<snip>>
This is the first study to demonstrate a decreased antioxidant defence
and increased oxidative damage to lipids, DNA and proteins in lichen
planus.
<<snip>>

Decreased antioxidant enzyme expression and increased oxidative damage
in erosive lichen planus of the vulva.
Sander CS, Cooper SM, Ali I, Dean D, Thiele JJ, Wojnarowska F
BJOG. 2005 Nov ; 112(11): 1572-5

The aim of this study was to investigate whether increased oxidative
stress occurs in erosive lichen planus of the vulva. Skin biopsies from
six patients with untreated, histologically confirmed erosive lichen
planus of the vulva were examined immunohistochemically using
antibodies against antioxidant enzymes. The protein-bound lipid
peroxidation products malondialdehyde (MDA) and 4-hydroxynonenale
(4-HNE) and the oxidative DNA damage marker 8-hydroxy-2'-deoxyguanosine
(8-OHdG) were investigated. Protein carbonyls as markers of protein
oxidation were visualised using the dinitrophenylhydrazone (DNPH)
method. Normal vulval tissues from 12 subjects served as controls. In
vulval lichen planus tissue the enzymatic antioxidant defence was found
to be significantly decreased in the epidermal layers. Furthermore, a
significant increase of lipid peroxidation products and oxidative DNA
damage was found within the epidermis. Protein oxidation occurred
predominantly in the papillary dermis. This is the first study to
demonstrate a decreased antioxidant defence and increased oxidative
damage to lipids, DNA and proteins in lichen planus. These oxidative
modifications point to pathophysiological alterations mainly within the
basal cell layers of the epidermis and at the dermoepidermal junction.
Further studies are warranted to investigate the potential role of
oxidative stress in the development of autoimmunity in this disease.

Abstract · PubMed · FullText · SFX · GS · Order · Clip ·
Citation · BibTeX · Related · TouchGraph · Scopus · References ·
Tag
tags: annotation:

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

Google