FAQFAQ   SearchSearch   MemberlistMemberlist   UsergroupsUsergroups 
 ProfileProfile   PreferencesPreferences   Log in to check your private messagesLog in to check your private messages   Log inLog in 
Forum index » Medicine forums » General talk
Inflammatory pulmonary diseases / iron-chelating therapy
Post new topic   Reply to topic Page 1 of 1 [1 Post] View previous topic :: View next topic
Author Message
ironjustice@aol.com
medicine forum Guru


Joined: 28 Apr 2005
Posts: 1522

PostPosted: Sun Jul 31, 2005 4:50 pm    Post subject: Inflammatory pulmonary diseases / iron-chelating therapy Reply with quote

Iron-binding drugs targeted to lysosomes: a potential strategy to treat
inflammatory lung disorders.
Persson HL, Richardson DR
Expert Opin Investig Drugs. 2005 Aug ; 14(Cool: 997-1008

In many inflammatory lung disorders, an abnormal assimilation of
redox-active iron will exacerbate oxidative tissue damage. It may be
that the most important cellular pool of redox-active iron exists
within lysosomes, making these organelles vulnerable to oxidative
stress. In experiments employing respiratory epithelial cells and
macrophages, the chelation of intra-lysosomal iron efficiently
prevented lysosomal rupture and the ensuing cell death induced by
hydrogen peroxide, ionising radiation or silica particles. Furthermore,
cell-permeable iron-binding agents (weak bases) that accumulate within
lysosomes due to proton trapping were much more efficient for
cytoprotection than the chelator, desferrioxamine. On a molar basis,
the weak base alpha-lipoic acid plus was 5000 times more effective than
desferrioxamine at preventing lysosomal rupture and apoptotic cell
death in cell cultures exposed to hydrogen peroxide. Thus,
iron-chelating therapy that targets the lysosome might be a future
treatment strategy for inflammatory pulmonary diseases.


Abstract PubMed FullText SFX LF+ GS Order Clip
Citation BibTeX Related TouchGraph Scopus References
Tag
tags: annotation:

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
Back to top
Google

Back to top
Display posts from previous:   
Post new topic   Reply to topic Page 1 of 1 [1 Post] View previous topic :: View next topic
The time now is Fri Oct 19, 2018 12:34 am | All times are GMT
Forum index » Medicine forums » General talk
Jump to:  

Similar Topics
Topic Author Forum Replies Last Post
No new posts Iron overload in endometriosis ironjustice@aol.com nutrition 0 Fri Jul 21, 2006 8:59 am
No new posts bb heat therapy eugeneshapiroisapig lyme 3 Thu Jul 20, 2006 9:39 am
No new posts Matrix metalloproteinase-9 / chlorogenic acid / iron chel... ironjustice@aol.com nutrition 1 Tue Jul 18, 2006 10:41 pm
No new posts Methamphetamine / iron / oxidative stress ironjustice@aol.com nursing 0 Tue Jul 18, 2006 1:19 pm
No new posts Brain iron deposition / cognition ironjustice@aol.com nutrition 0 Tue Jul 18, 2006 4:35 am

Copyright © 2004-2005 DeniX Solutions SRL
Other DeniX Solutions sites: email marketing campaigns , electronics forum, Science forum, Unix/Linux blog, Unix/Linux documentation, Unix/Linux forums


Powered by phpBB © 2001, 2005 phpBB Group
[ Time: 0.0120s ][ Queries: 16 (0.0027s) ][ GZIP on - Debug on ]