Deprivation of sex steroids / osteoporosis / iron

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

1: Osteoporos Int. 2005 Jul 5; [Epub ahead of print] Links

Osteoporosis in HFE2 juvenile hemochromatosis. A case report and review
of the literature.

Angelopoulos NG, Goula AK, Papanikolaou G, Tolis G.

Division of Endocrinology and Metabolism, "Hippokrateion" Hospital of
Athens, Vassilisis Sofias Avenue 108, 115 27, Athens, Greece,
drangelnick@hotmail.com.

Juvenile hemochromatosis (JH) is a severe form of hemochromatosis,
which involves rapid iron overload and leads to organ damage, typically
before the age of 30. We report a single case of a 25-year-old man
suffering from juvenile hemochromatosis, with aggressive clinical
manifestations, typically characterized by transaminasemia and
progressive erectile dysfunction, due to hypogonadotropic hypogonadism.
The clinical case appears interesting, as the patient also had
secondary osteoporosis accompanied by increased bone resorption, which
prevalently affected trabecular bone. Approximately 6 months after
normalization of serum ferritin levels was achieved by frequent
phlebotomies, he became eugonadal and bone mineral density of the
lumbar spine increased. Our observations suggest that osteoporosis
might occur in the state of JH even at a young age, mainly due to the
deprivation of sex steroids and the direct tissue toxicity of iron.

PMID: 15997423 [PubMed - as supplied by publisher]

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