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Roman Bystrianyk
medicine forum Guru
Joined: 02 May 2005
Posts: 454
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 Posted: Tue May 03, 2005 12:33 am Post subject:
Vitamins E and C Confirmed Safe at High Doses
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http://www.healthsentinel.com/news.php?event=news_print_list_item&id=785
"Vitamins E and C Confirmed Safe at High Doses", Medical News Today,
May 2, 2005,
Link: http://www.medicalnewstoday.com/medicalnews.php?newsid=23691
Fourteen leading safety and antioxidant experts reviewed the available
scientific literature on vitamins E and C and concluded vitamin E is
safe for the general population at intakes up to 1600 IU daily and
vitamin C is safe at up to 2000 mg daily, according to a new article
published in the April issue of the American Journal of Clinical
Nutrition (AJCN).
"This peer-reviewed expert analysis should help reassure consumers
about the safety of vitamin E for a healthy population at the most
common daily doses on the market -- 400 IU and 200 IU -- for vitamin E
single supplements," said John Hathcock, Ph.D., vice president,
scientific and international affairs, Council for Responsible Nutrition
(CRN), and the lead author on the article. However, Dr. Hathcock
pointed out that consumers should not view the study's conclusions as a
license to exceed recommended doses on product labels, noting that the
UL ("Tolerable Upper Intake Level") is a dose at which "there is no
known harm but it is not a recommendation or suggestion for daily use."
In reviewing the available scientific literature on vitamins E and C,
the scientists reviewed clinical trials as well as epidemiological
studies in humans, determining there was sufficient information from
human data to support a conclusion on safety. This is in contrast to
the approach taken by the Institute of Medicine (IOM), a scientific
advisory body, which established its UL for vitamin E based on an
extrapolation from animal data. The IOM set a UL at 1000 mg for vitamin
E (which is equivalent to 1000 IU synthetic; 1500 IU natural).
With regard to vitamin C, the authors noted that "Numerous studies of
vitamin C supplementation have provided no pattern of evidence to
support concerns about safety other than occasional gastrointestinal
upset or mild diarrhea..." The authors came to the same conclusion as
the IOM in establishing the UL at 2000 mg for vitamin C.
The review of the scientific literature encompassed 95 references,
including the recent, controversial meta-analysis on vitamin E from
Johns Hopkins University.
Vitamins E and C are among the most popular dietary supplements. Many
studies suggest that these antioxidant supplements, either alone or in
combination with other supplements, can help promote overall good
health and be helpful in lowering the risk of specific chronic
diseases, such as Alzheimer's, age-related macular degeneration,
cataracts, some types of cancer, and ischemic heart disease.
The article, titled "Vitamins E and C are safe across a broad range of
intakes," is available on-line at:
http://www.ajcn.org/cgi/content/full/81/4/736.
In addition to Dr. Hathcock, the authors include: Angelo Azzi, M.D.,
Ph.D., the University of Bern, Switzerland; Jeffrey Blumberg, Ph.D.,
Tufts University; Tammy Bray, Ph.D., Oregon State University,
Corvallis; Annette Dickinson, Ph.D., Council for Responsible Nutrition;
Balz Frei, Ph.D., Oregon State University, Corvallis; Ishwarlal Jialal,
M.D., Ph.D., University of California, Davis; Carol S. Johnston, Ph.D.,
Arizona State University, Mesa; Frank J. Kelly, Ph.D., King's College,
London, United Kingdom; Klaus Kraemer, Ph.D., formerly with BASF,
Germany; Lester Packer, Ph.D., University of Southern California, Los
Angeles; Sampath Parthasarathy, Ph.D., Louisiana State University, New
Orleans; Helmut Sies, M.D., Ph.D., Heinrich Heine University,
Dusseldorf, Germany; Maret G. Traber, Ph.D., Oregon State University,
Corvallis.
The Council for Responsible Nutrition (CRN), founded in 1973, is a
Washington, D.C.-based trade association representing dietary
supplement industry ingredient suppliers and manufacturers. CRN members
adhere to a strong code of ethics, comply with dosage limits and
manufacture dietary supplements to high quality standards under good
manufacturing practices.
Council for Responsible Nutrition http://www.crnusa.org |
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John H
medicine forum beginner
Joined: 03 May 2005
Posts: 16
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| Posted: Tue May 03, 2005 8:37 am Post subject:
Re: Vitamins E and C Confirmed Safe at High Doses
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The Council for Responsible Nutrition (CRN), founded in 1973, is a
Washington, D.C.-based trade association representing dietary
supplement industry ingredient suppliers and manufacturers.
Laymen like myself have to choose between sources of information.
In Feb05 Berkely University posted this information:
http://www.berkeleywellness.com/html/ds/dsVitaminE.php
Claims, Benefits: Helps prevent cancer, heart disease, cataracts.
Bottom Line: There's little or no clinical research showing that vitamin E
supplements are beneficial. Nearly all the clinical trials on E from the
past few years have yielded negative, inconclusive, or neutral results.
Thus, we no longer recommend supplements.
John |
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Rich
medicine forum Guru
Joined: 03 May 2005
Posts: 585
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| Posted: Tue May 03, 2005 10:30 am Post subject:
Re: Vitamins E and C Confirmed Safe at High Doses
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"John H" <JohnH@dotcomdotcom> wrote in message
news:4277546c$1@clear.net.nz...
| Quote: |
The Council for Responsible Nutrition (CRN), founded in 1973, is a
Washington, D.C.-based trade association representing dietary
supplement industry ingredient suppliers and manufacturers.
Laymen like myself have to choose between sources of information.
In Feb05 Berkely University posted this information:
http://www.berkeleywellness.com/html/ds/dsVitaminE.php
Claims, Benefits: Helps prevent cancer, heart disease, cataracts.
Bottom Line: There's little or no clinical research showing that vitamin E
supplements are beneficial. Nearly all the clinical trials on E from the
past few years have yielded negative, inconclusive, or neutral results.
Thus, we no longer recommend supplements.
John
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Vitamin E deficiency in humans is so rare as to be almost non-existant. It
occurs mostly in association with other disorders, such as post-gastrectomy.
Even a junk food diet is rich in Vitamin E because it is abundant in most
food fats. Most of the "benefits" are claimed for megadose use, and, as you
say, there is little evidence those benefits acrue.
--
--Rich De gustibus non est disputandum. |
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Roman Bystrianyk
medicine forum Guru
Joined: 02 May 2005
Posts: 454
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| Posted: Tue May 03, 2005 1:06 pm Post subject:
Re: Vitamins E and C Confirmed Safe at High Doses
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For your consideration:
Serum Alpha-Tocopherol Status in the United States Population: Findings
from the Third National Health and Nutrition Examination Survey
Ford, Earl S. and Sowell Anne, "Serum Alpha-Tocopherol Status in the
United States Population: Findings from the Third National Health and
Nutrition Examination Survey", American Journal of Epidemiology,
January 1, 1999, Vol. 150, Num. 3, pp. 290-300
"About 27% of the US population had a low alpha-tocopherol
concentration. ... These results show that important proportions of US
adults have a low serum alpha-tocopherol concentration, which may
increase their risk for chronic diseases in which low dietary intake or
blood concentration of alpha-tocopherol have been implicated." |
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PeterB
medicine forum Guru
Joined: 28 Apr 2005
Posts: 384
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| Posted: Tue May 03, 2005 1:33 pm Post subject:
Re: Vitamins E and C Confirmed Safe at High Doses
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John H wrote:
| Quote: | The Council for Responsible Nutrition (CRN), founded in 1973, is a
Washington, D.C.-based trade association representing dietary
supplement industry ingredient suppliers and manufacturers.
Laymen like myself have to choose between sources of information.
In Feb05 Berkely University posted this information:
http://www.berkeleywellness.com/html/ds/dsVitaminE.php
Claims, Benefits: Helps prevent cancer, heart disease, cataracts.
Bottom Line: There's little or no clinical research showing that
vitamin E
supplements are beneficial. Nearly all the clinical trials on E from
the
past few years have yielded negative, inconclusive, or neutral
results.
Thus, we no longer recommend supplements.
John
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Laymen like yourself should be better educated, evaluating the QUALITY
of information rather than attempting to choose between SOURCES of
information before making an informed decision. If you are waiting for
scientific studies to fall into lockstep on any matter relating to
public health, you are going to be very disappointed. You refer to The
Council for Responsible Nutrition, yet only provide a quotation and
link to Berkley's waffling after admitting they did exactly as you have
done -- giving more weight to recent studies simply because of that
fact. It so happens that many of the earlier studies were also of
higher quality, and often MUCH larger. The HOPE-TOO trial evaluated
only +70 year olds in poor health who were also on a variety of
prescription medications. A number of conventional drugs are known to
interfere with nutrient function and vitamin uptake.
See the link at CRN providing a list of vitamin E benefits supported in
the earlier studies: http://www.crnusa.org/vitaminEissafe.html and a
link discussing the poor quality of the recent negative vitamin E
trial, at
http://nutrition.about.com/od/researchstudies/a/vitaminecrn.htm.
Peter |
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Steve Cannon
medicine forum beginner
Joined: 03 May 2005
Posts: 1
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| Posted: Tue May 03, 2005 10:58 pm Post subject:
Re: Vitamins E and C Confirmed Safe at High Doses
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John H wrote:
| Quote: | The Council for Responsible Nutrition (CRN), founded in 1973, is a
Washington, D.C.-based trade association representing dietary
supplement industry ingredient suppliers and manufacturers.
Laymen like myself have to choose between sources of information.
In Feb05 Berkely University posted this information:
http://www.berkeleywellness.com/html/ds/dsVitaminE.php
Claims, Benefits: Helps prevent cancer, heart disease, cataracts.
Bottom Line: There's little or no clinical research showing that vitamin E
supplements are beneficial. Nearly all the clinical trials on E from the
past few years have yielded negative, inconclusive, or neutral results.
Thus, we no longer recommend supplements.
John
We want you to take PILLS from DRUG companies instead. . . |
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David Wright
medicine forum Guru
Joined: 25 Mar 2005
Posts: 750
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| Posted: Wed May 04, 2005 1:31 am Post subject:
Re: Vitamins E and C Confirmed Safe at High Doses
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In article <Gs6dnVIFSqing-XfRVn-tw@adelphia.com>,
Steve Cannon <stevecannon@me.com> wrote:
| Quote: | John H wrote:
The Council for Responsible Nutrition (CRN), founded in 1973, is a
Washington, D.C.-based trade association representing dietary
supplement industry ingredient suppliers and manufacturers.
Laymen like myself have to choose between sources of information.
In Feb05 Berkely University posted this information:
http://www.berkeleywellness.com/html/ds/dsVitaminE.php
Claims, Benefits: Helps prevent cancer, heart disease, cataracts.
Bottom Line: There's little or no clinical research showing that vitamin E
supplements are beneficial. Nearly all the clinical trials on E from the
past few years have yielded negative, inconclusive, or neutral results.
Thus, we no longer recommend supplements.
John
We want you to take PILLS from DRUG companies instead. . .
|
Where do you think vitamin E supplements come from? You think they
grow on trees?
-- David Wright :: alphabeta at prodigy.net
These are my opinions only, but they're almost always correct.
"His staff loves to say Bush is a man who doesn't know the
meaning of the word 'quit.' Well, apparently he's not all
that conversant with the word 'shame' either." (Will Durst) |
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