Coronary Artery Disease / IRON / ferritin

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

<<snip>>
recent proteomics and molecular biology studies have shown that
ferritin levels in arteries are increased in diseased tissues
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Clin Chim Acta. 2005 Jul;357(1):1-16. Epub 2005 Mar 23. Related
Articles, Links

Ferritin in atherosclerosis.

You SA, Wang Q.

Center for Molecular Genetics, Department of Molecular Cardiology,
ND4-38, Lerner Research Institute, and Center for Cardiovascular
Genetics, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland,
OH 44195, United States.

Iron, an essential element for many important cellular functions in all
living organisms, can catalyze the formation of potentially toxic free
radicals. Excessive iron is sequestered by ferritin in a nontoxic and
readily available form in a cell. Ferritin is composed of 24 subunits
of different proportions of two functionally distinct subunits:
ferritin H and L. The former is involved in ferroxidase activity
necessary for iron uptake and oxidation of ferrous iron, while the
latter is involved in nucleation of the iron core. The expression of
ferritin is under delicate control and is regulated at both the
transcriptional and posttranscriptional levels by iron, cytokines and
oxidative stress. Elevated ferritin levels are associated with an
increased risk of atherosclerotic coronary artery disease (CAD), the
leading cause of death and illness in developed countries. Serum
ferritin levels are a good indicator of iron stores in the body. In
fact, epidemiological studies have suggested that elevated serum
ferritin levels are associated with an increased risk of CAD and
myocardial infarction (MI), though inconsistent results were obtained
in some other studies. Moreover, recent proteomics and molecular
biology studies have shown that ferritin levels in arteries are
increased in diseased tissues, which further supports the link of
ferritin to CAD/MI. Future studies will determine whether increased
ferritin levels can serve as a distinct biomarker for the incidence of
CAD/MI and distinguish whether increased ferritin levels are a cause of
CAD or a consequence of the disease process.

PMID: 15963791 [PubMed - in process]

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