Accumulation of iron / breast cancer

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Free Radic Biol Med. 1999 Feb;26(3-4):348-54. Related Articles, Links

Alcohol-induced breast cancer: a proposed mechanism.

Wright RM, McManaman JL, Repine JE.

Webb-Waring Antioxidant Research Institute and University of Colorado
Health Sciences Center, Denver 80262, USA. richard.m.wright@uchsc.edu

Alcohol consumption increases the risk for breast cancer in women by
still undefined means. Alcohol metabolism is known to produce reactive
oxygen species (ROS), and breast cancer is associated with high levels
of hydroxyl radical (*OH) modified DNA, point mutations, single strand
nicks, and chromosome rearrangement. Furthermore, ROS modification of
DNA can produce the mutations and DNA damage found in breast cancer.
Alcohol dehydrogenase (ADH) and xanthine oxidoreductase (XOR) are
expressed and regulated in breast tissues and aldehyde oxidase (AOX)
may be present as well. Mammary gland XOR is an efficient source of
ROS. Recently, hepatic XOR and AOX were found to generate ROS in two
ways from alcohol metabolism: by acetaldehyde consumption and by the
intrinsic NADH oxidase activity of both XOR and AOX. The data obtained
suggests that: (1) expression of ADH and XOR or AOX in breast tissue
provides the enzymes that generate ROS; (2) metabolism of alcohol
produces acetaldehyde and NADH that can both be substrates for XOR or
AOX and thereby result in ROS formation; and (3) ROS generated by XOR
or AOX can induce the carcinogenic mutations and DNA damage found in
breast cancer. Accumulation of iron coupled with diminished antioxidant
defenses in breast tissue with advancing age provide additional support
for this hypothesis because both result in elevated ROS damage that may
exacerbate the risk for ROS-induced breast cancer.

Publication Types:
Review
Review, Tutorial

PMID: 9895226 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Google