Reducing subsequent CHD death risk by 97%?

Juhana Harju · medicine forum Guru Joined: 06 May 2005 Posts: 1056

Interesting approach, although I am suspicious of the high-dose statin.

Am J Cardiol. 2005 Feb 1;95(3):373-8. Related Articles, Links

A "poly-portfolio" for secondary prevention: a strategy to reduce subsequent
events by up to 97% over five years.

Robinson JG, Maheshwari N.

Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA.
jennifer-g-robinson@uiowa.edu

A "polypill" for the primary prevention of cardiovascular disease has been
proposed. We estimated the projected benefit of a secondary prevention
"poly-portfolio" strategy, including pharmacologic and lifestyle approaches
for those with coronary heart disease (CHD) or stroke. Based on recent
clinical trial results and clinical guidelines, combinations of a high-dose
statin, low to standard doses of antihypertensive therapy, aspirin, omega-3
fish oil, cardiac rehabilitation, and diet were evaluated. Patients with
CHD, post-myocardial infarction (MI), or stroke were projected to experience
84%, 91%, and 77% reductions, respectively, in CHD events from a
pharmacologic approach. Numbers of those needed to treat (NNT) for 5 years
were 9 to 11 to prevent 1 CHD event, and 21 to prevent 1 stroke. Post-MI
patients were projected to experience a 93% reduction in the risk of CHD
death (NNT 16) from a pharmacologic approach and a 97% reduction in the risk
of CHD death (NNT 15) with the addition of lifestyle changes. A secondary
prevention polyportfolio holds great promise for reducing the burden of
cardiovascular disease in the highest risk patients. PMID: 15670547

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15670547

--
Juhana

Google