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My Zetia Experience
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bornonce
medicine forum beginner


Joined: 15 Jun 2005
Posts: 9

PostPosted: Wed Jun 15, 2005 11:44 am    Post subject: My Zetia Experience Reply with quote

I am a 56-year old former competition ballroom dancer who had a
quadruple bypass about five years ago. After the surgery, my doctor put
me on Pravachol, which I tolerated well for about two years. However,
after about two years I began to notice uncharacteristic cramping and
soreness in the big body muscles, which got worse with time. One day I
ran out of Pravachol, and suddenly the worse of the cramping
dissappeared. When I resumed Pravachol, the symptoms reappeared.
Obviously my doctor and I agreed, I would stop taking a Statin.

I started taking Zetia (without a Statin) about six months after it was
available on the market, and had no noticeable side effects. Then late
last year strange things began to occur.

(1). After five years had lapsed since my surgery, I developed a hernia
right underneath my sternum at the point of the incision.
(2). I noticed that areas that were always muscular were becoming
flaccid and weakening. I particularly noticed unexplained fatty tissue
around the breasts.
(3). I had a FT/FSH test done, and the results were contradictory!
(4). This year I started to suffer a general feel of loss of muscle
mass, and started gaining flab in places that I never had flab (only
muscle) before dispite the fact that I had no diet change and was
getting the same amount (more actually) of exercise.
(5). This year I experienced abdominal soreness, as if I had being
doing 200 sit-ups the day before.
(6). This year I witnessed very unexplained flab gain in the abdomen,
despite the fact that I still use dance exercises and walk (hike,
actually) an hour a day.
(7). This year I felt as if the addominal muscles were losing all of
their strength, and it was uncomfortable to sit erect for more than a
few minutes.
(Cool. One morning my shoulder tighened severely, and caused pain both in
my upper left and right arms. Flexibility of the shoulder has always
been one of my strengths as a ballroom dancer. It felt like I had been
lifting weights above my head for two hours the day before.

Thnking that it might be drug-related, I stopped taking Niaspan for a
few days. No improvement. Next, I stopped taking Mycardis HCT for a few
days. Again, no discernible change. Then I stopped taking Zetia.

Two days later most of the pain was gone. I still had a little pain in
the upper left arm, but the shoulder stiffness was gone, as was the
pain in the right arm. Some of the soreness that I had been
experiencing in the thigh and the ankles also was gone.

Thinking that I must have sat wrong or some how had contorted my body I
started taking Zetia again.

Three hours after taking it the shoulder locked up again, with
incredible stiffness. Both arms ached so badly that it hurt to lift
them over my head. The awful feeling of adominal distention recurred,
as did pain in the thighs and calves. I stopped Zetia immediately, and
two days later most of the problems were gone.

I went for my annual physical last week and informed my doctor of
exactly what I had felt. There was no question in his mind - it was
RAPID MYOPATHY. My blood chemistry was normal, my LIPID profile was
excellent, and the testosterone tests were now within limits for my
age.

Since my LIPID profile was excellent, we decided to hold off on Zetia
until my next profile is taken (in about 3 months).

I still have the feeling of weak abdominal muscles, and a little pain
in the upper left arm, but the muscles seem to be gradually improving.
I am now adding running to my hiking in an attempt to get my abdomen
back to normal. Right now there is a lot of unexpained flab where there
used to be muscle. I can at least sit erectly when I play the piano now
(I used to play for four hours or so straight!). The discomfort is not
completely gone, but it is improving.

I believe that Statins and even Zetia are dangerous, and that
eventually anyone who takes them will start to see damaging side
effects. It took me TWO YEARS before Pravochol caused me problems, and
TWO YEARS before Zetia did. Some say that Statins are only problematic
if taken in large doses, but I contend that small doses for a long
period of time will eventually cause problems. The same with Zetia.

If you are taking Zetia, please be aware that MERCK recently changed
their story. Early studies and announcements indicated NO increase in
cases of myopathy (their studies lasted 12 weeks!) Post- marketing
studies are now showing cases of RAPID MYOPATHY. Although these cases
are supposedly "very rare", don't be surprised to see the same thing
happen with Zetia that happened with statins (the "very rare" became
much more common that first indicated). After long-term use, they
apparently become detrimental to normal body function, and cause muscle
damamge.

If I hadn't experienced it myself, I would have dismissed it as reports
confusing Zetia with the Zetia/w Statin cases. Believe me or don't
believe me, but forewarned is forearmed.
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Jason
medicine forum Guru


Joined: 29 Apr 2005
Posts: 1119

PostPosted: Wed Jun 15, 2005 1:16 pm    Post subject: Re: My Zetia Experience Reply with quote

In article <1118843061.549612.252260@g44g2000cwa.googlegroups.com>,
"bornonce" <bornonce@hotmail.com> wrote:

Quote:
I am a 56-year old former competition ballroom dancer who had a
quadruple bypass about five years ago. After the surgery, my doctor put
me on Pravachol, which I tolerated well for about two years. However,
after about two years I began to notice uncharacteristic cramping and
soreness in the big body muscles, which got worse with time. One day I
ran out of Pravachol, and suddenly the worse of the cramping
dissappeared. When I resumed Pravachol, the symptoms reappeared.
Obviously my doctor and I agreed, I would stop taking a Statin.

I started taking Zetia (without a Statin) about six months after it was
available on the market, and had no noticeable side effects. Then late
last year strange things began to occur.

(1). After five years had lapsed since my surgery, I developed a hernia
right underneath my sternum at the point of the incision.
(2). I noticed that areas that were always muscular were becoming
flaccid and weakening. I particularly noticed unexplained fatty tissue
around the breasts.
(3). I had a FT/FSH test done, and the results were contradictory!
(4). This year I started to suffer a general feel of loss of muscle
mass, and started gaining flab in places that I never had flab (only
muscle) before dispite the fact that I had no diet change and was
getting the same amount (more actually) of exercise.
(5). This year I experienced abdominal soreness, as if I had being
doing 200 sit-ups the day before.
(6). This year I witnessed very unexplained flab gain in the abdomen,
despite the fact that I still use dance exercises and walk (hike,
actually) an hour a day.
(7). This year I felt as if the addominal muscles were losing all of
their strength, and it was uncomfortable to sit erect for more than a
few minutes.
(Cool. One morning my shoulder tighened severely, and caused pain both in
my upper left and right arms. Flexibility of the shoulder has always
been one of my strengths as a ballroom dancer. It felt like I had been
lifting weights above my head for two hours the day before.

Thnking that it might be drug-related, I stopped taking Niaspan for a
few days. No improvement. Next, I stopped taking Mycardis HCT for a few
days. Again, no discernible change. Then I stopped taking Zetia.

Two days later most of the pain was gone. I still had a little pain in
the upper left arm, but the shoulder stiffness was gone, as was the
pain in the right arm. Some of the soreness that I had been
experiencing in the thigh and the ankles also was gone.

Thinking that I must have sat wrong or some how had contorted my body I
started taking Zetia again.

Three hours after taking it the shoulder locked up again, with
incredible stiffness. Both arms ached so badly that it hurt to lift
them over my head. The awful feeling of adominal distention recurred,
as did pain in the thighs and calves. I stopped Zetia immediately, and
two days later most of the problems were gone.

I went for my annual physical last week and informed my doctor of
exactly what I had felt. There was no question in his mind - it was
RAPID MYOPATHY. My blood chemistry was normal, my LIPID profile was
excellent, and the testosterone tests were now within limits for my
age.

Since my LIPID profile was excellent, we decided to hold off on Zetia
until my next profile is taken (in about 3 months).

I still have the feeling of weak abdominal muscles, and a little pain
in the upper left arm, but the muscles seem to be gradually improving.
I am now adding running to my hiking in an attempt to get my abdomen
back to normal. Right now there is a lot of unexpained flab where there
used to be muscle. I can at least sit erectly when I play the piano now
(I used to play for four hours or so straight!). The discomfort is not
completely gone, but it is improving.

I believe that Statins and even Zetia are dangerous, and that
eventually anyone who takes them will start to see damaging side
effects. It took me TWO YEARS before Pravochol caused me problems, and
TWO YEARS before Zetia did. Some say that Statins are only problematic
if taken in large doses, but I contend that small doses for a long
period of time will eventually cause problems. The same with Zetia.

If you are taking Zetia, please be aware that MERCK recently changed
their story. Early studies and announcements indicated NO increase in
cases of myopathy (their studies lasted 12 weeks!) Post- marketing
studies are now showing cases of RAPID MYOPATHY. Although these cases
are supposedly "very rare", don't be surprised to see the same thing
happen with Zetia that happened with statins (the "very rare" became
much more common that first indicated). After long-term use, they
apparently become detrimental to normal body function, and cause muscle
damamge.

If I hadn't experienced it myself, I would have dismissed it as reports
confusing Zetia with the Zetia/w Statin cases. Believe me or don't
believe me, but forewarned is forearmed.

bornonce,
I have read several stories similar to your story over the past couple of
weeks. You have a wonderful doctor. I agree with you and your
doctor--statins and Zetia were the cause of your muscle problems. I advise
you to buy this book since it has a list of alternatives to statins and
Zetia:
WHAT YOU MUST KNOW ABOUT STATIN DRUGS AND THEIR NATURAL ALTERNATIVES
by Jay S. Cohen, M.D.
Also visit Dr. Cohen's website: medicationsense.com
Thanks for your post--I believe you have helped lots of people.
My prayers are with you.
Jason

--
NEWSGROUP SUBSCRIBERS MOTTO
We respect those subscribers that ask for advice or provide advice.
We do NOT respect the subscribers that enjoy criticizing people.
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William Wagner
medicine forum Guru


Joined: 29 Apr 2005
Posts: 809

PostPosted: Wed Jun 15, 2005 1:44 pm    Post subject: Re: My Zetia Experience Reply with quote

In article <1118843061.549612.252260@g44g2000cwa.googlegroups.com>,
"bornonce" <bornonce@hotmail.com> wrote:

Quote:
I am a 56-year old former competition ballroom dancer who had a
quadruple bypass about five years ago. After the surgery, my doctor put
me on Pravachol, which I tolerated well for about two years. However,
after about two years I began to notice uncharacteristic cramping and
soreness in the big body muscles, which got worse with time. One day I
ran out of Pravachol, and suddenly the worse of the cramping
dissappeared. When I resumed Pravachol, the symptoms reappeared.
Obviously my doctor and I agreed, I would stop taking a Statin.

I started taking Zetia (without a Statin) about six months after it was
available on the market, and had no noticeable side effects. Then late
last year strange things began to occur.

(1). After five years had lapsed since my surgery, I developed a hernia
right underneath my sternum at the point of the incision.
(2). I noticed that areas that were always muscular were becoming
flaccid and weakening. I particularly noticed unexplained fatty tissue
around the breasts.
(3). I had a FT/FSH test done, and the results were contradictory!
(4). This year I started to suffer a general feel of loss of muscle
mass, and started gaining flab in places that I never had flab (only
muscle) before dispite the fact that I had no diet change and was
getting the same amount (more actually) of exercise.
(5). This year I experienced abdominal soreness, as if I had being
doing 200 sit-ups the day before.
(6). This year I witnessed very unexplained flab gain in the abdomen,
despite the fact that I still use dance exercises and walk (hike,
actually) an hour a day.
(7). This year I felt as if the addominal muscles were losing all of
their strength, and it was uncomfortable to sit erect for more than a
few minutes.
(Cool. One morning my shoulder tighened severely, and caused pain both in
my upper left and right arms. Flexibility of the shoulder has always
been one of my strengths as a ballroom dancer. It felt like I had been
lifting weights above my head for two hours the day before.

Thnking that it might be drug-related, I stopped taking Niaspan for a
few days. No improvement. Next, I stopped taking Mycardis HCT for a few
days. Again, no discernible change. Then I stopped taking Zetia.

Two days later most of the pain was gone. I still had a little pain in
the upper left arm, but the shoulder stiffness was gone, as was the
pain in the right arm. Some of the soreness that I had been
experiencing in the thigh and the ankles also was gone.

Thinking that I must have sat wrong or some how had contorted my body I
started taking Zetia again.

Three hours after taking it the shoulder locked up again, with
incredible stiffness. Both arms ached so badly that it hurt to lift
them over my head. The awful feeling of adominal distention recurred,
as did pain in the thighs and calves. I stopped Zetia immediately, and
two days later most of the problems were gone.

I went for my annual physical last week and informed my doctor of
exactly what I had felt. There was no question in his mind - it was
RAPID MYOPATHY. My blood chemistry was normal, my LIPID profile was
excellent, and the testosterone tests were now within limits for my
age.

Since my LIPID profile was excellent, we decided to hold off on Zetia
until my next profile is taken (in about 3 months).

I still have the feeling of weak abdominal muscles, and a little pain
in the upper left arm, but the muscles seem to be gradually improving.
I am now adding running to my hiking in an attempt to get my abdomen
back to normal. Right now there is a lot of unexpained flab where there
used to be muscle. I can at least sit erectly when I play the piano now
(I used to play for four hours or so straight!). The discomfort is not
completely gone, but it is improving.

I believe that Statins and even Zetia are dangerous, and that
eventually anyone who takes them will start to see damaging side
effects. It took me TWO YEARS before Pravochol caused me problems, and
TWO YEARS before Zetia did. Some say that Statins are only problematic
if taken in large doses, but I contend that small doses for a long
period of time will eventually cause problems. The same with Zetia.

If you are taking Zetia, please be aware that MERCK recently changed
their story. Early studies and announcements indicated NO increase in
cases of myopathy (their studies lasted 12 weeks!) Post- marketing
studies are now showing cases of RAPID MYOPATHY. Although these cases
are supposedly "very rare", don't be surprised to see the same thing
happen with Zetia that happened with statins (the "very rare" became
much more common that first indicated). After long-term use, they
apparently become detrimental to normal body function, and cause muscle
damamge.

If I hadn't experienced it myself, I would have dismissed it as reports
confusing Zetia with the Zetia/w Statin cases. Believe me or don't
believe me, but forewarned is forearmed.

Hi! I'd be very interested in an occasional update in regards to
getting muscle return (For lack of a better word) .

I just try to practice more (Work out). In your case dance which is a
different form of workout and difficult , joyful to do.

I dance slow and noticed degeneration slowly. Three years before I said
enough I did Zetia and Lipitor and zorcor at different dosages . I'm
slow but was scared big time with a 4 way CABG. All that and after an
initial drop in LDL increased dosage yielded a flat response. Then I
noticed my short term memory went to Hades.

Enough for me. Trying to get HDL up (Niacin) . BP stuff too. Now High
HDL may harm my eyesight.

Rock and a hard place comes to mind.


Hope it goes well with everyone.


Bill

--
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eml
medicine forum Guru Wannabe


Joined: 12 Jun 2005
Posts: 135

PostPosted: Wed Jun 15, 2005 3:29 pm    Post subject: Re: My Zetia Experience Reply with quote

If only my husband's lipitor toxicity had begun with muscle symptoms we
may have been clued into statins and their side effects.
unfortunately, it was 3+ yrs before he began experiencing a hand
tremor, which we did not connect with Lipitor.(his doisage--10
mgm/day--not a large dose at all) one yr later, he was diagnosed with
parkinson"s disease--as was a dear friend who had taken lipitor for 4
yrs. both men exhibited the same neuro symptoms. and were diagnosed
with parkinson's within 1 week of each other. I have been in contact
with 11 other individuals who feel their Parkinson's disease is
directly atrributable to statins. we are convinced that lipitor caused
mitochondrial dysfunction thru interfering with the production of coq10
via the mevalonate pathway. since coq10 is a vital element of complex
I, Complexes II/III and Complex V, any of these steps in the
mitochondrial electron chain could be compromised due to statins.
there is much research into Parkinson's disease and its relationship to
Complex I dysfunction--the possibility that statins cause overwhelming
oxidative stress within the mitochondria, resulting in mtDNA somatic
point mutations is another avenue to be researched in parkinson's
disease. these cases may be instances of a genetic variability
interacting with statins to produce a neurodegenerative disease.
however rarely this occurs., given the millions of individuals who are
taking this class of drugs, the number affected could be very large.
and no one is even considering looking at neurodegenerative diseassess
and statins--after all, most people taking statins are past middle
age--and most people who develop neurodegenerative disease are
also.....
do you know your reactive protein levels? how about homocysteine
levels? wonder if those would be helpful to obtain, you could discuss
with your doc...
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eml
medicine forum Guru Wannabe


Joined: 12 Jun 2005
Posts: 135

PostPosted: Wed Jun 15, 2005 3:33 pm    Post subject: Re: My Zetia Experience Reply with quote

i am unable to edit the above post--the last paragraph should include
"C-reactive protein" and homocysteine levels...
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Robert
medicine forum Guru


Joined: 28 Apr 2005
Posts: 1700

PostPosted: Wed Jun 15, 2005 3:39 pm    Post subject: Re: My Zetia Experience Reply with quote

"bornonce" <bornonce@hotmail.com> wrote in message
news:1118843061.549612.252260@g44g2000cwa.googlegroups.com...
Quote:
I am a 56-year old former competition ballroom dancer who had a
quadruple bypass about five years ago. After the surgery, my doctor put
me on Pravachol, which I tolerated well for about two years. However,
after about two years I began to notice uncharacteristic cramping and
soreness in the big body muscles, which got worse with time. One day I
ran out of Pravachol, and suddenly the worse of the cramping
dissappeared. When I resumed Pravachol, the symptoms reappeared.
Obviously my doctor and I agreed, I would stop taking a Statin.

I started taking Zetia (without a Statin) about six months after it was
available on the market, and had no noticeable side effects. Then late
last year strange things began to occur.

(1). After five years had lapsed since my surgery, I developed a hernia
right underneath my sternum at the point of the incision.
(2). I noticed that areas that were always muscular were becoming
flaccid and weakening. I particularly noticed unexplained fatty tissue
around the breasts.
(3). I had a FT/FSH test done, and the results were contradictory!
(4). This year I started to suffer a general feel of loss of muscle
mass, and started gaining flab in places that I never had flab (only
muscle) before dispite the fact that I had no diet change and was
getting the same amount (more actually) of exercise.
(5). This year I experienced abdominal soreness, as if I had being
doing 200 sit-ups the day before.
(6). This year I witnessed very unexplained flab gain in the abdomen,
despite the fact that I still use dance exercises and walk (hike,
actually) an hour a day.
(7). This year I felt as if the addominal muscles were losing all of
their strength, and it was uncomfortable to sit erect for more than a
few minutes.
(Cool. One morning my shoulder tighened severely, and caused pain both in
my upper left and right arms. Flexibility of the shoulder has always
been one of my strengths as a ballroom dancer. It felt like I had been
lifting weights above my head for two hours the day before.

Thnking that it might be drug-related, I stopped taking Niaspan for a
few days. No improvement. Next, I stopped taking Mycardis HCT for a few
days. Again, no discernible change. Then I stopped taking Zetia.

Two days later most of the pain was gone. I still had a little pain in
the upper left arm, but the shoulder stiffness was gone, as was the
pain in the right arm. Some of the soreness that I had been
experiencing in the thigh and the ankles also was gone.

Thinking that I must have sat wrong or some how had contorted my body I
started taking Zetia again.

Three hours after taking it the shoulder locked up again, with
incredible stiffness. Both arms ached so badly that it hurt to lift
them over my head. The awful feeling of adominal distention recurred,
as did pain in the thighs and calves. I stopped Zetia immediately, and
two days later most of the problems were gone.

I went for my annual physical last week and informed my doctor of
exactly what I had felt. There was no question in his mind - it was
RAPID MYOPATHY. My blood chemistry was normal, my LIPID profile was
excellent, and the testosterone tests were now within limits for my
age.

Since my LIPID profile was excellent, we decided to hold off on Zetia
until my next profile is taken (in about 3 months).

I still have the feeling of weak abdominal muscles, and a little pain
in the upper left arm, but the muscles seem to be gradually improving.
I am now adding running to my hiking in an attempt to get my abdomen
back to normal. Right now there is a lot of unexpained flab where there
used to be muscle. I can at least sit erectly when I play the piano now
(I used to play for four hours or so straight!). The discomfort is not
completely gone, but it is improving.

I believe that Statins and even Zetia are dangerous, and that
eventually anyone who takes them will start to see damaging side
effects. It took me TWO YEARS before Pravochol caused me problems, and
TWO YEARS before Zetia did. Some say that Statins are only problematic
if taken in large doses, but I contend that small doses for a long
period of time will eventually cause problems. The same with Zetia.

If you are taking Zetia, please be aware that MERCK recently changed
their story. Early studies and announcements indicated NO increase in
cases of myopathy (their studies lasted 12 weeks!) Post- marketing
studies are now showing cases of RAPID MYOPATHY. Although these cases
are supposedly "very rare", don't be surprised to see the same thing
happen with Zetia that happened with statins (the "very rare" became
much more common that first indicated). After long-term use, they
apparently become detrimental to normal body function, and cause muscle
damamge.

If I hadn't experienced it myself, I would have dismissed it as reports
confusing Zetia with the Zetia/w Statin cases. Believe me or don't
believe me, but forewarned is forearmed.


Buyer beware of any new drug on the market. Long term safety record does not
exist on any drug.
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bornonce
medicine forum beginner


Joined: 15 Jun 2005
Posts: 9

PostPosted: Wed Jun 15, 2005 4:57 pm    Post subject: Re: My Zetia Experience Reply with quote

Yes, my C-Reactive Protein and homocysteine levels have been well
within normal.

Thank you.
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bornonce
medicine forum beginner


Joined: 15 Jun 2005
Posts: 9

PostPosted: Wed Jun 15, 2005 5:09 pm    Post subject: Re: My Zetia Experience Reply with quote

To all of those who have asked, I am a 56 year old White MALE, 5'6",
135 lbs. I had angina for a few years before my heart surgery, which I
controlled with medications, but it was getting progressively worse. I
went in for an angioplasty in 12/99, but the cardiologist found total
blockage in three arteries, and 90% in another. I did not suffer a
heart attack or any heart damage, and the surgeon said that I had the
heart of a 30 yr old. (no fat! All of that dancing, I suppose. I used
to dance with three different partners, two hours a day!)

I currently only take Niaspan (500 mg at night, for overall
cardiovascular health), and Mycartis HCT (although my BP is normally
less than 120/80, I have "white-coat syndrome" sometimes, particularly
if I have to wait a long time in the waiting room! So I take Mycardis
HCT to handle worse-case BP under stress conditions).

Thanks for all of your comments.

Regards,
Michael
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Bill
medicine forum Guru


Joined: 06 May 2005
Posts: 849

PostPosted: Wed Jun 15, 2005 8:34 pm    Post subject: Re: My Zetia Experience Reply with quote

"bornonce" <bornonce@hotmail.com> wrote in message
news:1118843061.549612.252260@g44g2000cwa.googlegroups.com...
Quote:
I am a 56-year old former competition ballroom dancer who had a
quadruple bypass about five years ago. After the surgery, my doctor put
me on Pravachol, which I tolerated well for about two years. However,
after about two years I began to notice uncharacteristic cramping and
soreness in the big body muscles, which got worse with time. One day I
ran out of Pravachol, and suddenly the worse of the cramping
dissappeared. When I resumed Pravachol, the symptoms reappeared.
Obviously my doctor and I agreed, I would stop taking a Statin.

I started taking Zetia (without a Statin) about six months after it was
available on the market, and had no noticeable side effects. Then late
last year strange things began to occur.

(1). After five years had lapsed since my surgery, I developed a hernia
right underneath my sternum at the point of the incision.
(2). I noticed that areas that were always muscular were becoming
flaccid and weakening. I particularly noticed unexplained fatty tissue
around the breasts.
(3). I had a FT/FSH test done, and the results were contradictory!
(4). This year I started to suffer a general feel of loss of muscle
mass, and started gaining flab in places that I never had flab (only
muscle) before dispite the fact that I had no diet change and was
getting the same amount (more actually) of exercise.
(5). This year I experienced abdominal soreness, as if I had being
doing 200 sit-ups the day before.
(6). This year I witnessed very unexplained flab gain in the abdomen,
despite the fact that I still use dance exercises and walk (hike,
actually) an hour a day.
(7). This year I felt as if the addominal muscles were losing all of
their strength, and it was uncomfortable to sit erect for more than a
few minutes.
(Cool. One morning my shoulder tighened severely, and caused pain both in
my upper left and right arms. Flexibility of the shoulder has always
been one of my strengths as a ballroom dancer. It felt like I had been
lifting weights above my head for two hours the day before.

Thnking that it might be drug-related, I stopped taking Niaspan for a
few days. No improvement. Next, I stopped taking Mycardis HCT for a few
days. Again, no discernible change. Then I stopped taking Zetia.

Two days later most of the pain was gone. I still had a little pain in
the upper left arm, but the shoulder stiffness was gone, as was the
pain in the right arm. Some of the soreness that I had been
experiencing in the thigh and the ankles also was gone.

Thinking that I must have sat wrong or some how had contorted my body I
started taking Zetia again.

Three hours after taking it the shoulder locked up again, with
incredible stiffness. Both arms ached so badly that it hurt to lift
them over my head. The awful feeling of adominal distention recurred,
as did pain in the thighs and calves. I stopped Zetia immediately, and
two days later most of the problems were gone.

I went for my annual physical last week and informed my doctor of
exactly what I had felt. There was no question in his mind - it was
RAPID MYOPATHY. My blood chemistry was normal, my LIPID profile was
excellent, and the testosterone tests were now within limits for my
age.

Since my LIPID profile was excellent, we decided to hold off on Zetia
until my next profile is taken (in about 3 months).

I still have the feeling of weak abdominal muscles, and a little pain
in the upper left arm, but the muscles seem to be gradually improving.
I am now adding running to my hiking in an attempt to get my abdomen
back to normal. Right now there is a lot of unexpained flab where there
used to be muscle. I can at least sit erectly when I play the piano now
(I used to play for four hours or so straight!). The discomfort is not
completely gone, but it is improving.

I believe that Statins and even Zetia are dangerous, and that
eventually anyone who takes them will start to see damaging side
effects. It took me TWO YEARS before Pravochol caused me problems, and
TWO YEARS before Zetia did. Some say that Statins are only problematic
if taken in large doses, but I contend that small doses for a long
period of time will eventually cause problems. The same with Zetia.

If you are taking Zetia, please be aware that MERCK recently changed
their story. Early studies and announcements indicated NO increase in
cases of myopathy (their studies lasted 12 weeks!) Post- marketing
studies are now showing cases of RAPID MYOPATHY. Although these cases
are supposedly "very rare", don't be surprised to see the same thing
happen with Zetia that happened with statins (the "very rare" became
much more common that first indicated). After long-term use, they
apparently become detrimental to normal body function, and cause muscle
damamge.

If I hadn't experienced it myself, I would have dismissed it as reports
confusing Zetia with the Zetia/w Statin cases. Believe me or don't
believe me, but forewarned is forearmed.


There is a theory that some of the side effects of statins may have to do not
with some strange side chemical reaction, but the actual fact of lowering
cholesterol.

Bill
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serendipity1
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Joined: 05 May 2009
Posts: 1

PostPosted: Tue May 05, 2009 5:04 pm    Post subject: Zetia
Subject description: muscle cramping and aching all over
Reply with quote

Started on Statin drugs each one caused cramping. I was aware of rhabdomyolysis so I stopped them and Dr. put me on Zetia. Researched nothing about rhabdomyolysis. Since the last beating my ex husband gave me in December of 2008 I have had a steady decline and muscle aches and cramping at the sites which I had massive bruising. I believe it may be the catalyst to the start of the damage already done by the Zetia. I haave the same symptoms as everybody on this forum and now will stop taking the Zetia. Hope it helps. The medical problems I have faced over the last twenty years were caused by the physical and emaotional abuse inflicted on me by the ex. Hope is all I have left.
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