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Iron overload in endometriosis
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ironjustice@aol.com
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Joined: 28 Apr 2005
Posts: 1522

PostPosted: Fri Jul 21, 2006 8:59 am    Post subject: Iron overload in endometriosis Reply with quote

<<snip>>
Iron chelator treatment could therefore be beneficial in endometriosis
<<snip>>

Iron overload enhances epithelial cell proliferation in endometriotic
lesions induced in a murine model.
Defrère S, Van Langendonckt A, Vaesen S, Jouret M, Ramos RG, Gonzalez
D, Donnez J
Hum Reprod. 2006 Jul 18;

BACKGROUND: Iron deposits are characteristic of endometriotic lesions,
and pelvic iron concentrations are higher in endometriosis patients
than in women without endometriosis. In this study, the effect of iron
overload and iron chelation on the development of endometriosis in a
murine model was investigated. METHODS: Human menstrual endometrium was
injected i.p. into nude mice, either alone (controls) or supplemented
with erythrocytes or desferrioxamine (DFO), an iron chelator. After 5
days, the iron load of endometriosis-like lesions and peritoneal
macrophages and fluid was evaluated. Lesions were quantified by
immunohistochemical morphometry, and their proliferative activity was
assessed. RESULTS: Injection of erythrocytes into the pelvic cavity
caused iron overload in lesions (P < 0.025) and peritoneal macrophages
(P < 0.01) and fluid (P < 0.05), whereas DFO effectively reduced iron
status in lesions (P < 0.05) and macrophages (P < 0.01) compared with
controls. No difference was observed in the number or surface area of
lesions between the three groups. Erythrocytes increased (P < 0.05) and
DFO significantly decreased (P < 0.01) the proliferative activity of
lesions. CONCLUSIONS: Iron overload does not appear to affect lesion
establishment but may contribute to the further growth of endometriosis
by promoting cell proliferation of lesions. Iron chelator treatment
could therefore be beneficial in endometriosis to prevent iron overload
in the pelvic cavity and decrease cellular proliferation of lesions.

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