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Methamphetamine / iron / oxidative stress
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PostPosted: Tue Jul 18, 2006 1:19 pm    Post subject: Methamphetamine / iron / oxidative stress Reply with quote

Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced
Park MJ, Lee SK, Lim MA, Chung HS, Cho SI, Jang CG, Lee SM
Brain Res. 2006 Jul 14;

Methamphetamine (MA)-induced dopaminergic neurotoxicity is believed to
be associated with the increased formation of free radicals. This study
examined the effect of alpha-tocopherol (alpha-TC), a scavenger of
reactive oxygen species, and deferoxamine (DFO), an iron chelator, on
the MA-induced neurotoxicity. Male rats were treated with MA (10mg/kg,
every 2h for four injections). The rat received either alpha-TC (20
mg/kg) intraperitoneally for 3days and 30min prior to MA administration
or DFO (50 mg/kg) subcutaneously 30 min before MA administration. The
concentrations of dopamine (DA), serotonin and their metabolites
decreased significantly after MA administration, which was inhibited by
the alpha-TC and DFO pretreatment. alpha-TC and DFO attenuated the
MA-induced hyperthermia as well as the alterations in the locomotor
activity. The level of lipid peroxidation was higher and the reduced
glutathione concentration was lower in the MA-treated rats. These
changes were significantly attenuated by alpha-TC and DFO. This
suggests that alpha-TC and DFO ameliorate the MA-induced neuronal
damage by decreasing the level of oxidative stress.

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