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Insulin resistance in the development of disease
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ironjustice@aol.com
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Joined: 28 Apr 2005
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PostPosted: Mon Jul 17, 2006 2:10 pm    Post subject: Insulin resistance in the development of disease Reply with quote

<<snip>>
CONCLUSION: insulin resistance may play an important role as a source
of oxidative stress
<<snip>>

Protein oxidation in obesity and insulin resistance.
Atabek ME, Keskin M, Yazici C, Kendirci M, Hatipoglu N, Koklu E,
Kurtoglu S
Eur J Pediatr. 2006 May 19;

INTRODUCTION: Advanced oxidation protein products (AOPP) are considered
reliable markers to estimate the degree of oxidant-mediated protein
damage. Data on oxidative stress in childhood obesity and insulin
resistance are limited. OBJECTIVE: The aim of this study was to
investigate the AOPP level as an oxidative stress marker in obesity and
insulin resistance. The study included 57 pubertal obese children and
adolescents (30 girls and 27 boys) and 20 healthy pubertal children and
adolescents (11 girls and 9 boys). MATERIALS AND METHODS: All
participants in the obesity group underwent an oral glucose tolerance
test (OGTT) and two separate groups were formed according to the
existence of insulin resistance. RESULTS: AOPP levels were measured in
the obesity and control groups spectrophotometrically. The obesity
group consisted of 25 children and adolescents with insulin resistance
and 32 subjects without insulin resistance. AOPP levels in the obesity
group were found to be significantly higher than those in the control
group. Although AOPP levels in the subjects with insulin resistance
were higher than the subjects without insulin resistance, there was no
significant difference between AOPP levels of subgroups with insulin
resistance and without insulin resistance. CONCLUSION: This study
showed protein oxidation in obesity with a novel oxidative stress
marker and it also suggests that insulin resistance may play an
important role as a source of oxidative stress in the development of
other diseases after pubertal years.


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