FAQFAQ   SearchSearch   MemberlistMemberlist   UsergroupsUsergroups 
 ProfileProfile   PreferencesPreferences   Log in to check your private messagesLog in to check your private messages   Log inLog in 
Forum index » Medicine forums » nutrition
Iron induces insulin resistance
Post new topic   Reply to topic Page 1 of 1 [1 Post] View previous topic :: View next topic
Author Message
ironjustice@aol.com
medicine forum Guru


Joined: 28 Apr 2005
Posts: 1522

PostPosted: Mon Jul 17, 2006 1:36 pm    Post subject: Iron induces insulin resistance Reply with quote

Transferrin and iron induce insulin resistance of glucose transport in
adipocytes.
Green A, Basile R, Rumberger JM
Metabolism. 2006 Aug ; 55(Cool: 1042-5

Normal serum can increase the rate of lipolysis in isolated adipocytes.
Recently, we reported that the lipolytic effect of serum could be
partly explained by effects of iron and transferrin. To further
investigate these effects on fat cell metabolism, we have investigated
effects of serum, iron, and transferrin on glucose transport in
isolated rat adipocytes. Adipocytes were isolated by collagenase
digestion of rat epididymal fat pads, and glucose transport was
measured as uptake of [(3)H]2-deoxyglucose, measured in the presence of
0 to 25 ng/mL insulin. Insulin stimulated glucose transport
approximately 8- to 10-fold, with a half-maximally effective
concentration (EC(50)) of approximately 0.15 ng/mL. This was not
affected by 45-minute treatment with normal human serum. However, when
adipocytes were incubated with serum for 4 hours, cells became markedly
insulin resistant. This was manifested as decrease in maximally
stimulated glucose transport and a rightward shift in the dose-response
curve. Both FeS0(4) (3 mug/mL) and transferrin (100 mug/mL) had
similar, although less pronounced effects on insulin-stimulated glucose
transport. Treatment of adipocytes with palmitic acid (120 mumol/L),
representing the concentration of fatty acids released into the media
after 4 hours of serum treatment, did not alter the effect of insulin
on glucose transport. We conclude that transferrin and iron induce
insulin resistance of glucose transport in adipocytes through a
mechanism independent of fatty acids. These findings may further
explain the association between body iron stores and risk of type 2
diabetes mellitus.



Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Back to top
Google

Back to top
Display posts from previous:   
Post new topic   Reply to topic Page 1 of 1 [1 Post] View previous topic :: View next topic
The time now is Fri Apr 27, 2018 4:26 am | All times are GMT
Forum index » Medicine forums » nutrition
Jump to:  

Similar Topics
Topic Author Forum Replies Last Post
No new posts Iron overload in endometriosis ironjustice@aol.com nutrition 0 Fri Jul 21, 2006 8:59 am
No new posts Matrix metalloproteinase-9 / chlorogenic acid / iron chel... ironjustice@aol.com nutrition 1 Tue Jul 18, 2006 10:41 pm
No new posts Methamphetamine / iron / oxidative stress ironjustice@aol.com nursing 0 Tue Jul 18, 2006 1:19 pm
No new posts Brain iron deposition / cognition ironjustice@aol.com nutrition 0 Tue Jul 18, 2006 4:35 am
No new posts Elevated levels of free iron / hypomyelination ironjustice@aol.com nutrition 0 Tue Jul 18, 2006 4:22 am

Copyright © 2004-2005 DeniX Solutions SRL
Other DeniX Solutions sites: email marketing campaigns , electronics forum, Science forum, Unix/Linux blog, Unix/Linux documentation, Unix/Linux forums


Powered by phpBB © 2001, 2005 phpBB Group
[ Time: 0.0119s ][ Queries: 16 (0.0023s) ][ GZIP on - Debug on ]