\"Jan Drew\"
medicine forum Guru
Joined: 02 Mar 2006
Posts: 353
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 Posted: Sat Jul 08, 2006 10:24 pm Post subject:
http://www.medicalnewstoday.com/medicalnews.php?newsid=46340&nfid=nl
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http://www.medicalnewstoday.com/medicalnews.php?newsid=46340&nfid=nl
Researchers Present Phase 2 Clinical Results For Acologix AC-100
Researchers from Acologix (Hayward, CA, USA), the University of California
(San Francisco, USA), and the University of Connecticut (Simsbury, USA) will
announce the results of a Phase 2 clinical trial of AC-100 (also known as
Dentonin), reporting that it met its primary goal of stimulating the
formation of new dentin when applied directly to tooth defects, and
demonstrating that AC-100 has a favorable safety profile.
Administration of AC-100 resulted in a clear trend in stimulating the
formation of new dentin, compared with a placebo. This effect was seen
across a wide variety of cavity depths. Importantly, the efficacy of AC-100
was seen most dramatically in the deepest cavities (RDT < 0.5 mm), where the
clinical utility of the approach is most needed.
Because of its unique hard-tissue-regenerating properties, the researchers
believe that AC-100 represents a novel approach to promoting dentin
formation and could be a promising treatment for patients undergoing a wide
range of dental restoration procedures. Drilling during these procedures can
irritate the dental pulp and reduce the dentin layer that protects the pulp,
causing pain and sensitivity, and sometimes leading to complications,
including tooth loss. Therefore, it may be beneficial to stimulate the
formation of new dentin to protect the pulp from this damage.
Results and the method of application of AC-100 used in this Phase 2
clinical study demonstrate that a novel biological approach to dentistry can
be introduced as a supplement to routine dental care.
AC-100 is a novel synthetic peptide derived from an endogenous human protein
produced by bone and dental cells. In addition to dental applications, it is
being studied for periodontal, oral bone, dental implant, and orthopedic
applications.
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This is a summary of Abstract #545, "AC-100, Novel Biological Approach to
Promoting Dentin Formation in Humans," by M. Lazarov, J.D. Fellmann, D.M.
Rosen, P. DenBesten, and C. Pameijer (Acologix, Hayward, CA, USA; University
of California-San Francisco, USA; University of Connecticut, Simsbury, USA),
presented on June 29, 2006, at the Brisbane Convention & Exhibition Centre,
during the 84th General Session of the International Association for Dental
Research. |
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