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Toprol XL inhibited by antioxidants?
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jackmax
medicine forum beginner


Joined: 08 Jul 2006
Posts: 1

PostPosted: Sat Jul 08, 2006 6:37 pm    Post subject: Toprol XL inhibited by antioxidants? Reply with quote

My wife has labile blood pressure that spikes really high. Her
physican prescribed Toprol XL which didn't seem to help much until she
stopped using Vitamin E supplements when the blood pressure suddenly
stabilized. We found one refence online (University of Maryland
website) theorizing that Vitamin E inhibits the effect of beta blockers
like Toprol, but have been unable to verify that information.

Last night, her blood pressure spiked again, after she had been eating
a lot of blueberries for a couple of days. Is it possible that the
antioxidant effect of blueberries is acting the same as the vitamin E
in reducing the effect of Toprol? Are there any studies that might
shed more light on this effect including other foods to be avoided?
Thank you very much.
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Andrew B. Chung, MD/PhD
medicine forum Guru


Joined: 25 Mar 2005
Posts: 8540

PostPosted: Sat Jul 08, 2006 7:09 pm    Post subject: Re: Toprol XL inhibited by antioxidants? Reply with quote

jackmax wrote:
Quote:
My wife has labile blood pressure that spikes really high. Her
physican prescribed Toprol XL which didn't seem to help much until she
stopped using Vitamin E supplements when the blood pressure suddenly
stabilized. We found one refence online (University of Maryland
website) theorizing that Vitamin E inhibits the effect of beta blockers
like Toprol, but have been unable to verify that information.

Last night, her blood pressure spiked again, after she had been eating
a lot of blueberries for a couple of days. Is it possible that the
antioxidant effect of blueberries is acting the same as the vitamin E
in reducing the effect of Toprol? Are there any studies that might
shed more light on this effect including other foods to be avoided?

Toprol XL is a substrate for CYP450:D6 which is subject to a lot of
interindividual variability. It is certainly possibly that your wife's
CYP450:D6 system is activated ny antioxidants such as vitamin E and
similar compounds in the blueberries.

Quote:
Thank you very much.

You are welcome.

All thanks and praises belong to the LORD, Whom I love with all my
being.

Prayerfully in Christ's amazing love,

Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://tinyurl.com/frep8
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