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Iron driven gum disease
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Joined: 28 Apr 2005
Posts: 1522

PostPosted: Fri Jul 07, 2006 4:24 pm    Post subject: Iron driven gum disease Reply with quote

Most adults over 60 in this country have lost all their teeth,
primarily due to periodontal disease.

As many as half of high school students have gingivitis.


Reactive oxygen species generation in gingival fibroblasts of Down
syndrome patients detected by electron spin resonance spectroscopy.
Komatsu T, Lee MC, Miyagi A, Shoji H, Yoshino F, Maehata Y, Maetani T,
Kawamura Y, Ikeda M, Kubota E
Redox Rep. 2006; 11(2): 71-7

Oral manifestations of Down syndrome include high susceptibility to
gingival inflammation with early onset and rapidly progressive
periodontitis. The influence of reactive oxygen species (ROS) on
periodontitis of Down syndrome is unclear. The aim of this study was to

characterize ROS formation in Down syndrome-gingival fibroblasts
(DS-GF) using electron spin resonance (ESR) spin trapping with
5,5-dimetyl-1-pyrolline-N-oxide (DMPO), and to determine whether ROS
generation plays a role in the pathogenesis of periodontitis in Down
syndrome patients. We observed formation of the DMPO-OH spin adduct,
indicating HO(*) generation from cultured DS-GF and non-DS-GF. The
increased HO(*) generation in cultured DS-GF was strongly decreased in
the presence of the H(2)O(2) scavenger, catalase, or the iron chelator,

desferal. This may due to the enzymatic ability of over-expressed
CuZn-superoxide dismutase in Down syndrome to catalyze the formation of

H(2)O(2) from O(2)(*-), thereby increasing the availability of
substrate H(2)O(2) for the iron dependent generation of HO(*) via the
Fenton reaction, suggesting that HO(*) generated from DS-GF may be
involved in progressive periodontitis of Down syndrome.

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