Iron driven gum disease

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Reactive oxygen species generation in gingival fibroblasts of Down
syndrome patients detected by electron spin resonance spectroscopy.
Komatsu T, Lee MC, Miyagi A, Shoji H, Yoshino F, Maehata Y, Maetani T,
Kawamura Y, Ikeda M, Kubota E
Redox Rep. 2006; 11(2): 71-7

Oral manifestations of Down syndrome include high susceptibility to
gingival inflammation with early onset and rapidly progressive
periodontitis. The influence of reactive oxygen species (ROS) on
periodontitis of Down syndrome is unclear. The aim of this study was to
characterize ROS formation in Down syndrome-gingival fibroblasts
(DS-GF) using electron spin resonance (ESR) spin trapping with
5,5-dimetyl-1-pyrolline-N-oxide (DMPO), and to determine whether ROS
generation plays a role in the pathogenesis of periodontitis in Down
syndrome patients. We observed formation of the DMPO-OH spin adduct,
indicating HO(*) generation from cultured DS-GF and non-DS-GF. The
increased HO(*) generation in cultured DS-GF was strongly decreased in
the presence of the H(2)O(2) scavenger, catalase, or the iron chelator,
desferal. This may due to the enzymatic ability of over-expressed
CuZn-superoxide dismutase in Down syndrome to catalyze the formation of
H(2)O(2) from O(2)(*-), thereby increasing the availability of
substrate H(2)O(2) for the iron dependent generation of HO(*) via the
Fenton reaction, suggesting that HO(*) generated from DS-GF may be
involved in progressive periodontitis of Down syndrome.

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