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Cancer drug versus natural substances
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ironjustice@aol.com
medicine forum Guru


Joined: 28 Apr 2005
Posts: 1522

PostPosted: Thu Jul 06, 2006 9:38 am    Post subject: Cancer drug versus natural substances Reply with quote

<<snip>>
Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), may have similar
chemotherapeutic effects on cancer cells as 5-fluorouracil (5-FU),
<<snip>>

Comparison of potential chemotherapeutic agents, 5-fluoruracil, green
tea, and thymoquinone on colon cancer cells.
Norwood AA, Tan M, May M, Tucci M, Benghuzzi H
Biomed Sci Instrum. 2006; 42: 350-6

Antioxidants have been found to be quite successful in deterring
certain disease processes for years, especially cancer. Antioxidants
protect the body by neutralizing the free radicals and donating one of
their own electrons, thus ending the scavenger reaction.
Epigallocatechin-3-gallate (EGCG), the most abundant catechin found in
green tea, is a valuable scavenger of reactive oxygen species in vitro
as well as in vivo. Thymoquinone (TQ), a major active component of
black seed (Nigella sativa), is also known for its powerful scavenger
abilities as an inhibitor of oxidative stress and has been utilized in
the Middle East for centuries for healing properties. These two potent
antioxidants when compared to the chemotherapeutic drug of choice,
5-fluorouracil (5-FU), have demonstrated incredible chemotherapeutic
responses to the SW-626 cell line. The objective of this study was to
evaluate and compare the effects of SW-626 colon cancer cells after a
24, 48, and 72 hour incubation periods with low, medium, and high doses
of EGCG, TQ, and 5-FU. Cell viability, cell number, cellular
morphology, and cellular metabolism were compared for the control and
treatment groups. The results of this study evidenced a similar
significant decrease in cell number as early as 24 hours in the groups
treated with TQ and EGCG compared to 5-FU. Increases in cellular damage
were evident after 24, 48, and 72 hours and in all treated groups
compared with the control. Reduced cell numbers in the treated groups
suggests the possibility that TQ and EGCG may have similar
chemotherapeutic effects on cancer cells as 5-FU.




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Tom


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pmoran@bordernet.com.au
medicine forum beginner


Joined: 28 May 2006
Posts: 35

PostPosted: Thu Jul 06, 2006 9:14 pm    Post subject: Re: Cancer drug versus natural substances Reply with quote

<ironjustice@aol.com> wrote in message
news:1152178717.642263.160750@m79g2000cwm.googlegroups.com...
Quote:
snip
Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), may have similar
chemotherapeutic effects on cancer cells as 5-fluorouracil (5-FU),
snip

Comparison of potential chemotherapeutic agents, 5-fluoruracil, green
tea, and thymoquinone on colon cancer cells.
Norwood AA, Tan M, May M, Tucci M, Benghuzzi H
Biomed Sci Instrum. 2006; 42: 350-6

Antioxidants have been found to be quite successful in deterring
certain disease processes for years, especially cancer. Antioxidants
protect the body by neutralizing the free radicals and donating one of
their own electrons, thus ending the scavenger reaction.
Epigallocatechin-3-gallate (EGCG), the most abundant catechin found in
green tea, is a valuable scavenger of reactive oxygen species in vitro
as well as in vivo. Thymoquinone (TQ), a major active component of
black seed (Nigella sativa), is also known for its powerful scavenger
abilities as an inhibitor of oxidative stress and has been utilized in
the Middle East for centuries for healing properties. These two potent
antioxidants when compared to the chemotherapeutic drug of choice,
5-fluorouracil (5-FU), have demonstrated incredible chemotherapeutic
responses to the SW-626 cell line. The objective of this study was to
evaluate and compare the effects of SW-626 colon cancer cells after a
24, 48, and 72 hour incubation periods with low, medium, and high doses
of EGCG, TQ, and 5-FU. Cell viability, cell number, cellular
morphology, and cellular metabolism were compared for the control and
treatment groups. The results of this study evidenced a similar
significant decrease in cell number as early as 24 hours in the groups
treated with TQ and EGCG compared to 5-FU. Increases in cellular damage
were evident after 24, 48, and 72 hours and in all treated groups
compared with the control. Reduced cell numbers in the treated groups
suggests the possibility that TQ and EGCG may have similar
chemotherapeutic effects on cancer cells as 5-FU.

Don't run out and buy this stuff unless you are really desperate. It is

virtually meaningless research. I wonder who is financing it?

Everything is toxic to cancer cells in tissue culture and you can make any
agent work or not work by simply changing its concentration (note no mention
of what concentrations were used). . Also most colon cancer cell lines do
NOT respond to 5 fluorouracil. It is not the "agent of choice" for colon
cancer nowadays.

Also high doses of antioxidants such as vitamin C have been well-tried with
cancer, both in conventional and alternative circles and they have no
noticeable effect. It is possible that high doses of intravenous
antioxidants may have a useful anti-cancer effect because of their
pro-oxidant activity in very high concentrations, but the track record of
intravenous vitamin C is so far not very impressive.

Peter Moran
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ironjustice@aol.com
medicine forum Guru


Joined: 28 Apr 2005
Posts: 1522

PostPosted: Thu Jul 06, 2006 10:41 pm    Post subject: Re: Cancer drug versus natural substances Reply with quote

Peter Moran wrote:
Quote:
ironjustice@aol.com> wrote in message
news:1152178717.642263.160750@m79g2000cwm.googlegroups.com...
snip
Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), may have similar
chemotherapeutic effects on cancer cells as 5-fluorouracil (5-FU),
snip

Also high doses of antioxidants such as vitamin C have been well-tried with
cancer,.

Peter Moran

Do you think there is a .. key .. 'difference' .. between the
anti-oxidant .. vitamin C and the anti-oxidants ..
Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), .. ?

Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), .. chelate / bind
up .. iron .. whereas .. ascorbate isn't all that .. good .. as an iron
chelator .. ?


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Back to top
pmoran@bordernet.com.au
medicine forum beginner


Joined: 28 May 2006
Posts: 35

PostPosted: Fri Jul 07, 2006 12:28 am    Post subject: Re: Cancer drug versus natural substances Reply with quote

<ironjustice@aol.com> wrote in message
news:1152225694.373631.133640@m79g2000cwm.googlegroups.com...
Quote:

Peter Moran wrote:
ironjustice@aol.com> wrote in message
news:1152178717.642263.160750@m79g2000cwm.googlegroups.com...
snip
Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), may have similar
chemotherapeutic effects on cancer cells as 5-fluorouracil (5-FU),
snip

Also high doses of antioxidants such as vitamin C have been well-tried
with
cancer,.

Peter Moran

Do you think there is a .. key .. 'difference' .. between the
anti-oxidant .. vitamin C and the anti-oxidants ..
Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), .. ?

Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), .. chelate / bind
up .. iron .. whereas .. ascorbate isn't all that .. good .. as an iron
chelator .. ?


Many patients with cancer become severely iron deficient, in fact some kinds
of cancer often declare their presence only as severe iron deficiency anemia
without halting the progress of the cancer. Why, then, would you think
the ability of a drug to chelate iron would confer on it the ability to
attack cancer?

Peter Moran
Quote:


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Back to top
ironjustice@aol.com
medicine forum Guru


Joined: 28 Apr 2005
Posts: 1522

PostPosted: Fri Jul 07, 2006 12:52 am    Post subject: Re: Cancer drug versus natural substances Reply with quote

Peter Moran wrote:

Quote:
Many patients with cancer become severely iron deficient, in fact some kinds
of cancer often declare their presence only as severe iron deficiency anemia
without halting the progress of the cancer. Why, then, would you think
the ability of a drug to chelate iron would confer on it the ability to
attack cancer?

Encased by the chelator, the iron is no longer available to perform its
role in vital jobs. like transporting oxygen, and the cancer cell dies.


Quote:

Peter Moran


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Back to top
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