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The inflammatory consequences of psychologic stress
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William Wagner
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Joined: 29 Apr 2005
Posts: 809

PostPosted: Wed Jul 05, 2006 12:33 pm    Post subject: The inflammatory consequences of psychologic stress Reply with quote

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt
=Abstract&list_uids=16781084&query_hl=1&itool=pubmed_docsum

or http://tinyurl.com/o7slp

Not knowing what visceral adipocytes were I found this hypothesis.
due to Andrews post.

"The inflammatory cytokines from visceral adipocytes are simply
deleterious.  They must be eliminated to reach the goal of optimal
health.
Prayerfully in Christ's amazing love,
Andrew B. Chung "

Thanks Andrew !

Bill

..................................

1: Med Hypotheses. 2006 Jun 14; [Epub ahead of print]
Related Articles, Links
 
The inflammatory consequences of psychologic stress: Relationship to
insulin resistance, obesity, atherosclerosis and diabetes mellitus, type
II.

Black PH.

Department of Microbiology, Boston University School of Medicine, 715
Albany Street, Room L-501, Boston, MA 02118, United States.

Inflammation is frequently present in the visceral fat and vasculature
in certain patients with cardiovascular disease (CVD) and/or adult onset
Diabetes Mellitus Type II (NIDDM). An hypothesis is presented which
argues that repeated acute or chronic psychologically stressful states
may cause this inflammatory process. The mediators are the major stress
hormones norepinephrine (NE) and epinephrine (E) and cortisol together
with components of the renin-angiotensin system (RAS), the
proinflammatory cytokines (PIC), as well as free fatty acids (ffa), the
latter as a result of lipolysis of neutral fat. NE/E commence this
process by activation of NF(kappa)B in macrophages, visceral fat, and
endothelial cells which induces the production of toll-like receptors
which, when engaged, produce a cascade of inflammatory reactions
comprising the acute phase response (APR) of the innate immune system
(IIS). The inflammatory process is most marked in the visceral fat depot
as well as the vasculature, and is involved in the metabolic events
which culminate in the insulin resistance/metabolic syndromes (IRS/MS),
the components of which precede and comprise the major risk factors for
CVD and NIDDM. The visceral fat has both the proclivity and capacity to
undergo inflammation. It contains a rich blood and nerve supply as well
as proinflammatory molecules such as interleukin 6 (IL-6), tumor
necrosis factor alpha (TNFalpha), leptin, and resistin, the
adipocytokines, and acute phase proteins (APP) which are activated from
adipocytes and/or macrophages by sympathetic signaling. The inflammation
is linked to fat accumulation. Cortisol, IL-6, angiotensin II (angio
II), the enzyme 11(beta) hydroxysteroid dehydrogenase-1 and positive
energy balance, the latter due to increased appetite induced by the
major stress hormones, are factors which promote fat accumulation and
are linked to obesity. There is also the capacity of the host to limit
fat expansion. Sympathetic signaling induces TNF which stimulates the
production of IL-6 and leptin from adipocytes; these molecules promote
lipolysis and ffa fluxes from adipocytes. Moreover, catecholamines and
certain PIC inhibit lipoprotein lipase, a fat synthesizing enzyme. The
brain also participates in the regulation of fat cell mass; it is
informed of fat depot mass by molecules such as leptin and ffa. Leptin
stimulates corticotrophin releasing hormone in the brain which
stimulates the SNS and HPA axes, i.e. the stress response. Also, ffa
through portal signaling from the liver evoke a similar stress response
which, like the response to psychologic stress, evokes an innate immune
response (IIR), tending to limit fat expansion, which culminates in
inflammatory cascades, the IRS-MS, obesity and disease if prolonged.
Thus, the brain also has the capacity to limit fat expansion. A
competition apparently exists between fat expansion and fat loss. In
"western" cultures, with excessive food ingestion, obesity frequently
results. The linkage of inflammation to fat metabolism is apparent since
weight loss diminishes the concentration of inflammatory mediators. The
linkage of stress to inflammation is all the more apparent since the
efferent pathways from the brain in response to fat signals, which
results in inflammation to decrease and limit fat cell mass, is the same
as the response to psychologic stress, which strengthens the hypothesis
presented herein.

PMID: 16781084 [PubMed - as supplied by publisher]

--
S Jersey USA Zone 5 Shade
This article is posted under fair use rules in accordance with
Title 17 U.S.C. Section 107, and is strictly for the educational
and informative purposes. This material is distributed without profit.
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Andrew B. Chung, MD/PhD
medicine forum Guru


Joined: 25 Mar 2005
Posts: 8540

PostPosted: Wed Jul 05, 2006 12:53 pm    Post subject: Re: The inflammatory consequences of psychologic stress Reply with quote

William Wagner wrote:
Quote:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt
=Abstract&list_uids=16781084&query_hl=1&itool=pubmed_docsum

or http://tinyurl.com/o7slp

Not knowing what visceral adipocytes were I found this hypothesis.
due to Andrews post.

"The inflammatory cytokines from visceral adipocytes are simply
deleterious. They must be eliminated to reach the goal of optimal
health.
Prayerfully in Christ's amazing love,
Andrew B. Chung "

Thanks Andrew !

You are welcome.

All thanks and praises belong to GOD, Whom I love with all my being.

I would change the title to "the inflammatory consequences of
overeating."

Many folks overeat because of psychological stress making them hunger
but as many lose their appetite in the face of psychological stress.
Thus, the focus should, instead, be on the overeating which arises from
the overarching fear of hunger, which arises from things that our body
regards as healthy.

Prayerfully in Christ's amazing love,

Andrew B. Chung
Cardiologist, Atlanta, Georgia, USA
http://HeartMDPhD.com/TheLife
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outsource@citnett.com
medicine forum beginner


Joined: 05 Jul 2006
Posts: 1

PostPosted: Wed Jul 05, 2006 3:17 pm    Post subject: Re: The inflammatory consequences of psychologic stress Reply with quote

The "inflammatory cytokines" from internal belly fat is only part of the
picture as it relates to weight and related matters. The fat in fact
starts to act as an endo organ producing hormones which act as feedforward
messengers for appetite perception and weight status. If one accepts the
"starvation" theory of the metabolic syndrom and diabetes where every
chance to store energy in fat during the good times for the hard times as
a precautionary modification in metabolism, then this makes sense as an
adaptation and ot a disorder, the definition of which is relative to
survival effect of course.
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