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Treatment of cancer / iron chelating drugs
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ironjustice@aol.com
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PostPosted: Sat Jul 01, 2006 4:15 pm    Post subject: Treatment of cancer / iron chelating drugs Reply with quote

Iron mobilization from transferrin and non-transferrin-bound-iron by
deferiprone. Implications in the treatment of thalassemia, anemia of
chronic disease, cancer and other conditions.
Kontoghiorghes GJ
Hemoglobin. 2006; 30(2): 183-200

Iron mobilization from transferrin is one of the most important
screening methods for the selection of chelators intended for clinical
use in the treatment of iron overload in thalassemia and other
conditions. In vitro and in vivo screening of approved and experimental
chelating drugs has shown that only the alpha-ketohydroxypyridines
deferiprone (L1) and 1-allyl-2 methyl-3-hydroxypyrid-4-one (L1NAll),
are effective in the mobilization of iron from transferrin. Iron
mobilization from transferrin and non-transferrin-bound-iron (NTBI) can
be used to optimize existing chelation therapy protocols for the
treatment of iron loaded patients. New chelation strategies involving
L1 and its combination with deferoxamine (DFO) and other chelators can
be used to increase iron excretion and reduce or prevent excess iron
deposition in the heart and other vital organs of iron loaded patients
by comparison to monotherapies. Deferiprone and its combinations may
also have potential applications in the treatment of cancer, the anemia
of chronic disease and other conditions.


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