Diabetic retinopathy / iron chelator

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Obesity & Diabetes WeekWelcome to NewsRx!

Diabetic Retinopathy
Adverse angiogenesis in diabetic retinopathy may be averted by iron
chelator
June 19th, 2006

Adverse angiogenesis in diabetic retinopathy may be averted by iron
chelator.
"Hyperglycemia-induced mitochondrial overproduction of reactive
oxygen species leads to the activation of different biochemical
pathways involved in endothelial damage of the diabetic retina.
Tenilsetam [±-3-(2-thienyl)-2-piperazinone] is a dicarbonyl scavenger
in the millimolar range and a transition metal ion chelator in the
micromolar range," scientists in Germany report.

"We tested its effect on experimental diabetic retinopathy, and on
endothelial cell characteristics in vitro. Streptozotocin diabetic male
Wistar rats (60 mg/kg BW) received 50 mg/kg BW tenilsetam (D-T)...

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

--------------------------------------------------------------------------------
Source: Obesity & Diabetes Week (2006-06-19)

outsor@citynet.net · medicine forum Guru Joined: 11 Sep 2005 Posts: 569

Good on it, as long as we recall that iron is not the cause for diabetes
in the first place. In sa process of several stages iron was involved in
one stage, while oxygen was involved in all of them. No support for the
iron causes all disease because people eat meat notion.

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes

Diabetes Care. 2006 May;29(5):1090-5. Related Articles, Links

Common presence of non-transferrin-bound iron among patients with type
2 diabetes.

Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider RC.

Department of Preventive Medicine, School of Medicine, Kyungpook
University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422.
lee...@knu.ac.kr.

OBJECTIVE: Recently, we reported increased cardiovascular disease
mortality among supplemental vitamin C users with type 2 diabetes in a
prospective cohort study. Because vitamin C may cause oxidative stress
in the presence of redox active iron, we hypothesized that
non-transferrin-bound iron (NTBI), a form of iron susceptible to redox
activity, may be present in patients with type 2 diabetes. RESEARCH
DESIGN AND METHODS: We measured serum NTBI levels using
high-performance liquid chromatography in 48 patients with known
diabetes (at least 5 years duration since diagnosis), 49 patients with
newly diagnosed diabetes, and 47 healthy control subjects (frequency
matched on age and sex). RESULTS: NTBI was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes.

Mean NTBI values varied significantly between the three groups, with
the highest values being observed in patients with known diabetes and
the lowest in the control subjects (0.62 +/- 0.43 vs. 0.24 +/- 0.29 vs.

0.04 +/- 0.13 mumol/l Fe). Serum total iron or percent transferrin
saturation were very similar among the three groups, yet NTBI was
strongly associated with serum total iron (r = 0.74, P < 0.01) and
percent transferrin saturation (r = 0.70, P < 0.01) among the patients
with known diabetes. CONCLUSIONS: Consistent with our hypothesis, these

data demonstrate the common existence of NTBI in type 2 diabetic
patients with a strong gradient with severity. Prospective cohort
studies are required to clarify the clinical relevance of increased
NTBI levels.

PMID: 16644642 [PubMed - in process]

--------------------------------------------------------------------------------

Obesity & Diabetes Week

Diabetic Retinopathy
Adverse angiogenesis in diabetic retinopathy may be averted by iron
chelator
June 19th, 2006

Adverse angiogenesis in diabetic retinopathy may be averted by iron
chelator.
"Hyperglycemia-induced mitochondrial overproduction of reactive
oxygen species leads to the activation of different biochemical
pathways involved in endothelial damage of the diabetic retina.
Tenilsetam [±-3-(2-thienyl)-2-piperazinone] is a dicarbonyl scavenger
in the millimolar range and a transition metal ion chelator in the
micromolar range," scientists in Germany report.

"We tested its effect on experimental diabetic retinopathy, and on
endothelial cell characteristics in vitro. Streptozotocin diabetic male

Wistar rats (60 mg/kg BW) received 50 mg/kg BW tenilsetam (D-T)...

-----------------------------------------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

outsor@citynet.net · medicine forum Guru Joined: 11 Sep 2005 Posts: 569

"RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in
diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes"

Yes, and iron still doesn't cause diabetes as other research shows. Even
the above proves it, not all newly diagnosed had the iron result and the
higher levels appeared only after complications appeared over time, it is
a dog and tail thing, again, ho hum.

Beav · medicine forum Guru Wannabe Joined: 02 May 2005 Posts: 100

<outsor@citynet.net> wrote in message
news:44a172ae$0$76288$4d5ecec7@reader.city-net.com...

Trinkwasser · medicine forum beginner Joined: 01 Jul 2006 Posts: 1

On Wed, 28 Jun 2006 21:06:18 GMT, "Beav"
<beavis.original@ntlwoxorld.com> wrote:

Google