Severity of pain in fibromyalgia / oxidative stress

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

<<snip>>
Supplementation of antioxidant vitamins such as vitamins C and E may be
indicated.
<<snip>>

Total antioxidant capacity and the severity of the pain in patients
with fibromyalgia.
Altindag O, Celik H
Redox Rep. 2006; 11(3): 131-5

The purpose of the study was to determine the oxidative and
antioxidative status of plasma in patients with fibromyalgia. Total
antioxidant capacity (TAC) of plasma was significantly lower in
patients with fibromyalgia (n = 20) than in healthy controls (n = 20)
[1.5 (SD 0.3) and 1.9 (SD 0.3) mmol Trolox equiv./l, P = 0.001]. In
contrast, the total peroxide level of plasma was significantly higher
in patients than in healthy controls [37.4 (SD 6.7) and 33.0 (SD 2.7)
mumol H(2)O(2)/l; P = 0.01]. The oxidative stress index (OSI) level was
significantly higher in patients with fibromyalgia than in healthy
controls [2.5 (SD 1.0) and 1.8 (SD 0.4); P = 0.007]. A significant
negative correlation between visual analogue scale (VAS) and TAC level
was determined (r = -0.79, P < 0.001). The present results indicate
that patients with fibromyalgia are exposed to oxidative stress and
this increased oxidative stress may play a role in the etiopathogenesis
of the disease. Supplementation of antioxidant vitamins such as
vitamins C and E to the therapy may be indicated.

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