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Alzheimers intervention ? / lecithin
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Joined: 28 Apr 2005
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PostPosted: Thu Jun 22, 2006 10:46 pm    Post subject: Alzheimers intervention ? / lecithin Reply with quote

Acetylcholinesterase inhibitors for Alzheimer's disease:
anti-inflammatories in acetylcholine clothing!
Tabet N
Age Ageing. 2006 Jul ; 35(4): 336-8

The pathogenesis of Alzheimer's disease (AD) has been linked to a
deficiency in the brain neurotransmitter acetylcholine. Subsequently,
acetylcholinesterase inhibitors (AChEIs) were introduced for the
symptomatic treatment of AD. The prevailing view has been that the
efficacy of AChEIs is attained through their augmentation of
acetylcholine-medicated neuron to neuron transmission. However, AChEIs
also protect cells from free radical toxicity and beta-amyloid-induced
injury, and increased production of antioxidants. In addition, it has
been reported that AChEIs directly inhibit the release of cytokines
from microglia and monocytes. These observations are supported by
evidence showing a role for acetylcholine in suppression of cytokine
release through a 'cholinergic anti-inflammatory pathway'. Based on the
accumulating research data so far, it is no longer appropriate to
consider that the sole action of AChEIs in AD is through direct
acetylcholine-medicated enhancement of neuronal transmission. Evidence
points to a possible anti-inflammatory role for these agents as well.


Lecithin may therefore be the method of choice for
accelerating acetylcholine synthesis

Lancet. 1977 Jul 9;2(8028):68-9. Related Articles, Links

Lecithin consumption raises serum-free-choline levels.

Wurtman RJ, Hirsch MJ, Growdon JH.

Consumption of choline by rats sequentially increases serum-choline,
brain-choline, and brain-acetylcholine concentrations. In man
consumption of choline increases in levels in the serum and
cerebrospinal fluid; its administration is an effective way of treating

tardive dyskinesia. We found that oral lecithin is considerably more
effective in raising human serum-choline levels than an equivalent
quantity of choline chloride. 30 minutes after ingestion of choline
chloride (2-3 g free base), serum-choline levels rose by 86% and
returned to normal values within 4 hours; 1 hour after lecithin
ingestion, these levels rose by 265% and remained significantly raised
for 12 hours. Lecithin may therefore be the method of choice for
accelerating acetylcholine synthesis by increasing the availability of
choline, its precursor in the blood.

PMID: 69151 [PubMed - indexed for MEDLINE]


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