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Imbalances in metal and oxidative stress in Alzheimer's disease
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PostPosted: Tue Jun 20, 2006 6:50 pm    Post subject: Imbalances in metal and oxidative stress in Alzheimer's disease Reply with quote

<<snip>>
**pathological** role of oxidative stress
<<snip>>

Ann Ist Super Sanita. 2005;41(2):143-64. Related Articles, Links


Metal ions and oxidative protein modification in neurological disease.

Sayre LM, Moreira PI, Smith MA, Perry G.

Department of Chemistry, Case Western Reserve University, Cleveland, OH
44106, USA. lms3@po.cwru.edu

This review highlights the role of oxidative stress and imbalances in
metal ion homeostasis in the neurodegenerative diseases Alzheimer's
disease and Parkinson's disease and in the progressive demyelinating
disease multiple sclerosis. The chemistry and biochemistry of oxidative
stress-induced protein damage are first described, followed by the
evidence for a pathological role of oxidative stress in these disease
states. It is tempting to speculate that free radical oxygen chemistry
contributes to pathogenesis in all these conditions, though it is as
yet undetermined what types of oxidative changes occur early in the
disease, and what types are secondary manifestations of neuronal
degeneration.

Publication Types:
Review

PMID: 16244388 [PubMed - indexed for MEDLINE]

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