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Oxidative stress in Alzheimer's disease
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ironjustice@aol.com
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Joined: 28 Apr 2005
Posts: 1522

PostPosted: Tue Jun 20, 2006 6:23 pm    Post subject: Oxidative stress in Alzheimer's disease Reply with quote

Pathophysiology. 2006 Jun 14; [Epub ahead of print] Links


Oxidative stress in Alzheimer's disease.

Chauhan V, Chauhan A.

NYS Institute for Basic Research in Developmental Disabilities, 1050
Forest Hill Road, Staten Island, NY 10314, USA.

Oxidative damage is a major feature in the pathophysiology of
Alzheimer's disease (AD). In this review, we discuss free
radical-mediated damage to the biochemical components involved in the
pathology and clinical symptoms of AD. We explain how amyloid
beta-protein (Abeta), microtubule-associated protein tau, presenilins,
apolipoprotein E, mitochondria and proteases play a role in increasing
oxidative stress in AD. Abeta not only can induce oxidative stress, but
its generation is also increased as a result of oxidative stress.
Finally, a hypothetical model linking oxidative stress with
beta-amyloid and neurofibrillary tangle pathology in AD is proposed.

PMID: 16781128 [PubMed - as supplied by publisher]

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Bud
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Joined: 26 Feb 2006
Posts: 16

PostPosted: Tue Jun 20, 2006 6:36 pm    Post subject: Re: Oxidative stress in Alzheimer's disease Reply with quote

ironjustice@aol.com wrote:

Sigh. After perusing many of your recent and past posts I cannot find a
justification for reading more of your useless 'scientific articles' so
PLONK!
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