Insight into the anti-cancer effect of exercise

Roman Bystrianyk · medicine forum Guru Joined: 02 May 2005 Posts: 454

"Insight into the anti-cancer effect of exercise", Yahoo, May 29, 2006,
Link:
http://news.yahoo.com/s/nm/20060529/hl_nm/effect_exercise_dc;_ylt=AjbAsQs3x68qyyqbTZvdkxMQ.3QA;_ylu=X3oDMTA5aHJvMDdwBHNlYwN5bmNhdA--

The anti-cancer effects of exercise are due to increases in a protein
that blocks cell growth and induces cell death, according to Australian
researchers.

The protein, called insulin-like binding protein-3 (IGFBP-3), inhibits
another protein called insulin-like growth factor-1 (IGF-1), thereby
blocking IGF-1's proliferative effect on cell growth, the study hints.

Dr. Andrew M. M. Haydon and colleagues at Manash Medical School in
Melbourne identified new cases of colorectal cancer in the Melbourne
Collaborative Cohort Study, a prospective study of 41,528 adults
recruited between 1990 and 1994.

The investigators looked at baseline body mass index and level of
physical activity reported and compared baseline levels of IGF-1or
IGFBP-3 with those measurements.

Analyses centered on 443 colon cancer patients followed for more than 5
years.

Among subjects who were physically active, an increase in IGFBP-3 was
associated with a 48 percent reduction in colon cancer-specific deaths.
No association was apparent for IGF-1.

For the physically inactive, there was no association between IGF-1 or
IGFBP-3 and colon cancer survival.

Haydon told Reuters Health that that "physical activity can increase
IGFBP-3 levels, which, in turn, reduces the amount of free IGF-1."
IGF-1 has been shown to stimulate cell growth, inhibit cell death, and
promote angiogenesis -- the formation of new blood vessels, which
tumors need to grow.

"We did not look at the amount of physical activity needed to reduce
colorectal cancer incidence, as we only looked at those from our cohort
who had CRC," Haydon pointed out.

"Other studies that have looked at this have shown a dose-effect,
meaning the more exercise the lower the risk, however our study did not
try to address this issue. We were examining the effect of physical
activity on one's prognosis following a diagnosis of bowel cancer and
the possible mechanisms behind this effect."

SOURCE: Gut, May 2006.

David White · medicine forum beginner Joined: 04 May 2005 Posts: 7

Roman Bystrianyk wrote:

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