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statins for 10 year olds
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TC
medicine forum Guru


Joined: 02 May 2005
Posts: 1814

PostPosted: Fri Jun 02, 2006 8:54 pm    Post subject: statins for 10 year olds Reply with quote

http://today.reuters.co.uk/news/newsArticle.aspx?type=healthNews&storyID=2006-06-02T193622Z_01_N17244362_RTRIDST_0_HEALTH-BIZFEATURE-CHOLESTEROL-KIDS-DC.XML

Kids with cholesterol take statins like mom, dad
Fri Jun 2, 2006 8:36 PM BST

By Debra Sherman

CHICAGO (Reuters) - Cholesterol is making inroads in kindergartens on
piles of pizza and burgers, and children as young as 10 are taking
statin drugs along with their vitamins to stay healthy.

Poor diets and lack of exercise are the same factors behind rising
childhood obesity, and can lead to health problems later in life,
notably heart disease, doctors said.

"Genetics play a role, but this is more a lifestyle problem," said Dr.
Steven Nissen, interim chairman of cardiology at the Cleveland Clinic.

Bad cholesterol builds up plaque on artery walls that narrows arteries
and blocks blood flow to the heart. High cholesterol also is linked to
other health problems, such as strokes.

Nissen said he occasionally prescribes hugely popular
cholesterol-lowering statins -- by far the world's biggest selling
class of drugs -- to children when changes in diet and exercise fail to
do the job.

"I've treated children as young as 10 with them. I'd have to have a
compelling reason to do that. Safety data is limited," he added.

Nissen, who primarily sees adult heart patients, said he has treated
some children with extremely high cholesterol levels approaching 400.

The American Heart Association says total blood cholesterol for
children and adolescents, 2 to 19 years old should be under 170 and a
number over 200 is too high. The AHA advises LDL cholesterol, or
so-called "bad" cholesterol, should be below 110 and HDL cholesterol,
or "good" cholesterol, should be above 35.

A 2002 study funded my Merck & Co., maker of the popular statin Zocor,
found that the drugs didn't affect the growth or maturation of the
children. A total of 173 children were included in the study. Similar
studies yielded similar results.

Statistics on the number of prescriptions written for children were not
available from major health organizations.

However, the number seems to be rising, said Dr. Stephen Daniels, head
of pediatrics at the Children's Hospital in Denver, Colorado.

"My impression is that physicians recognize high cholesterol more
frequently and that has partly to do with obesity, but also a more
general awareness in about cholesterol and that's happening more in
pediatrics," Daniels said.

However, he noted that LDL, or bad cholesterol, is less affected by
obesity than HDL, or good cholesterol. Approved drugs on the U.S.
market do not address HDL, but drug companies are hoping to introduce
them soon.

Low HDL and high LDL have independent risks and it is not known which
is worse, Daniels said. But it is clear that the build-up of plaque
causes hardening of the arteries, or atherosclerosis, and that develops
at an early age, he added.

PREVENTION THE BEST ROUTE

Daniels said he believes the potential risks of prescribing statins to
children are outweighed by the benefits.

"Cardiovascular disease can start at childhood and there's a need for
primary prevention during childhood," said Dr. Gautam Singh, runs one
of the few preventive heart programs for children at St. Louis
Children's Hospital.

"We have found in our experience, as opposed to adults, that if
children lose just 5 to 10 percent of their body weight, there can be a
15 to 20 percent reduction in their bad cholesterol. We see it all the
time."

Last year, the clinic saw about 200 children aged 6 to 18, and Singh
said he only prescribed statins to children who were at least 10 years
old. Patients had strong risk factors such as a total cholesterol level
of over 250 who were not improving with diet and exercise.

Dr. Sarah de Ferranti, who works in the pediatric cardiology clinic at
Children's Hospital in Boston, said insurers now recognize that
childhood cholesterol was a health problem that deserved treatment and
reimbursement.

"There's increased interest in prevention on the part of insurers," she
said.

***********

Steven E. Nissen, M.D., F.A.C.C., Medical Director, Cardiovascular
Coordinating Center, Cleveland Clinic, Cleveland. Principal
investigator on "Statin Therapy, LDL Cholesterol, C-Reactive Protein,
and Coronary Artery Disease," which was funded by Pfizer. Served as a
consultant to AstraZeneca, Atherogenics, Lipid Sciences, Wyeth,
Novartis, Pfizer, Sankyo, Takeda, Kowa, Sanofi, Novo-Nordisk, Eli
Lilly, Kos Pharmaceuticals, GlaxoSmithKline, Forbes Medi-tech, and
Merck-Schering Plough. Served as a lecturer for AstraZeneca and
Pfizer, and receives funding from AstraZeneca, Takeda, Sankyo, Pfizer,
Atherogenics, and Lipid Sciences for ongoing clinical trials. (N Engl J
Med. 2005;352:29-38.) Research on lipid-lowering therapy on progression
of coronary atherosclerosis through the use of statins Pravachol
(pravastatin) and Lipitor (atorvastatin) funded by Pfizer. Research
support from AstraZeneca, Merck-Schering Plough, Esperion Therapeutics,
Takeda, Pfizer, and Sankyo. (JAMA. 2004;291:1071-80) Principal
investigator on the CAMELOT study of amlodipine (Norvasc) vs. enalapril
for hypertension, which was funded by Pfizer. (JAMA. 2004;292:2217-26.)
Consultant or research support from Pfizer, Merck, AstraZeneca, Sankyo,
Takeda Pharmaceuticals North America, Guidant, Aventis, Fournier,
Boston Scientific, Pharmacyclics, Celltech, and Esperion.
(http://www.lipidhealth.org/content/newsletter/vol6no4/pg3.asp;
accessed 3/23/05)

********

Stephen R. Daniels, M.D., Ph.D., Professor and Associate Chairman,
Heart Center Cincinnati Children's Hospital Medical Center. Received
grants from Pfizer in 2004, while a visiting professor at Medical
University of South Carolina Children's Hospital.
(http://www.promisingminds.com/GrantsProgType.aspx?ProgID=301&ProgAreaID=2&ProgTypeID=1&PrevGrant=1;
accessed 5/3/05)

********
Talk about drug dealers and their efforts to sell to kids.

These guys should lose their medical licenses and substitute them with
drug pedalling licenses.

Hey Doug Freese, are you OK with this crap?

TC
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Mr-Natural-Health
medicine forum Guru


Joined: 01 May 2005
Posts: 1807

PostPosted: Fri Jun 02, 2006 9:12 pm    Post subject: Re: 10 year old TC, sure does love to complain :( Reply with quote

TC is a jeunvile for posting such crap. :(

TC sure does like to complain.

This ng is NOT sci.med or sci.pharmacology.

Just thought that the juvenile known as TC might want to know.
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TC
medicine forum Guru


Joined: 02 May 2005
Posts: 1814

PostPosted: Fri Jun 02, 2006 9:29 pm    Post subject: statins for children Reply with quote

FOAD, ya dumb f**k.

It is none of your frikking business what I post in a public forum.

TC

Mr. Natural-Health wrote:
Quote:
TC is a jeunvile for posting such crap. :(

TC sure does like to complain.

This ng is NOT sci.med or sci.pharmacology.

Just thought that the juvenile known as TC might want to know.
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Mr-Natural-Health
medicine forum Guru


Joined: 01 May 2005
Posts: 1807

PostPosted: Sat Jun 03, 2006 2:17 am    Post subject: Re: 10 year old TC, sure does love to complain :( Reply with quote

Mr. Natural-Health wrote:
Quote:
TC is a jeunvile for posting such crap. :(

TC sure does like to complain.

This ng is NOT sci.med or sci.pharmacology.

Just thought that the juvenile known as TC might want to know.
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Davide
medicine forum beginner


Joined: 07 May 2006
Posts: 25

PostPosted: Sat Jun 03, 2006 12:49 pm    Post subject: Re: statins for 10 year olds Reply with quote

TC ha scritto:

Quote:
http://today.reuters.co.uk/news/newsArticle.aspx?type=healthNews&storyID=2006-06-02T193622Z_01_N17244362_RTRIDST_0_HEALTH-BIZFEATURE-CHOLESTEROL-KIDS-DC.XML

Kids with cholesterol take statins like mom, dad
Fri Jun 2, 2006 8:36 PM BST

By Debra Sherman

cut

********
Talk about drug dealers and their efforts to sell to kids.

These guys should lose their medical licenses and substitute them with
drug pedalling licenses.

AGREE !

Davide
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