Can some predispositions be for balancing lifespan?

Kumar · medicine forum Guru Joined: 10 May 2005 Posts: 870

"Control of Insulin Secretion
Insulin is secreted in primarily in response to elevated blood
concentrations of glucose. This makes sense because insulin is "in
charge" of facilitating glucose entry into cells. Some neural stimuli
(e.g. site and taste of food) and increased blood concentrations of
other fuel molecules, including amino acids and fatty acids, also
promote insulin secretion.

Our understanding of the mechanisms behind insulin secretion remain
somewhat fragmentary. Nonetheless, certain features of this process
have been clearly and repeatedly demonstrated, yielding the following
model:

Glucose is transported into the B cell by facilitated diffusion through

a glucose transporter; elevated concentrations of glucose in
extracellular fluid lead to elevated concentrations of glucose within
the B cell.

Elevated concentrations of glucose within the B cell ultimately leads
to membrane depolarization and an influx of extracellular calcium. The
resulting increase in intracellular calcium is thought to be one of the

primary triggers for exocytosis of insulin-containing secretory
granules. The mechanisms by which elevated glucose levels within the B
cell cause depolarization is not clearly established, but seems to
result from metabolism of glucose and other fuel molecules within the
cell, perhaps sensed as an alteration of ATP:ADP ratio and transduced
into alterations in membrane conductance.

Increased levels of glucose within B cells also appears to activate
calcium-independent pathways that participate in insulin secretion.
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/pancreas/insu...

"

In view of above, it is indicative that glucose levels can activate
some
physiological activities related to movement of bio-substances?

Can abnormal levels of glucose effect vascular tone, vascular
preambility to it and cells unwillingness for intake of excess glucose?

Google