Black bean / angiogenesis / cancer proliferation

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Cancer Lett. 2005 Feb 10;218(2):153-62. Related Articles, Links

Inhibition of Caco-2 colon, MCF-7 and Hs578T breast, and DU 145
prostatic cancer cell proliferation by water-soluble black bean
condensed tannins.

Bawadi HA, Bansode RR, Trappey A 2nd, Truax RE, Losso JN.

Food Protein Biotechnology Laboratory, School of Human Ecology,
Louisiana State University Agricultural Center, 111 Food Science
Building, Baton Rouge, LA 70803, USA.

The potential anti-angiogenic activities of water-soluble condensed
tannins isolated from black beans were evaluated using HEL 299 normal
human fibroblast lung cells, Caco-2 colon, MCF-7 and Hs578T breast, and
DU 145 human prostatic cancer cells. Condensed tannins at 0.24-24muM
did not affect the growth of normal cells, but dose-dependently induced
cancer cell death by apoptosis as shown by a concentration-dependent
decrease in ATP and cell gross morphology. After 24h exposure to
Caco-2, MCF-7, Hs578T, and DU 145 cancer cells, water-soluble black
bean condensed tannins at 24muM suppressed fetal bovine serum
stimulated cell migration, the secretion of matrix metalloproteinase-2
(MMP-2 or gelatinase A), matrix metalloproteinase-9 (MMP-9 or
gelatinase B), and vascular endothelial growth factor VEGF(165)
receptor expression by the cancer cells in the conditioned media. The
potential health enhancing properties of condensed tannins from black
beans as inhibitors of angiogenesis is discussed.

PMID: 15670892 [PubMed - in process]

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