|
|
| Author |
Message |
listener
medicine forum Guru
Joined: 05 May 2005
Posts: 617
|
 Posted: Mon May 09, 2005 10:11 pm Post subject:
Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
Nov. 9, 2004 (New Orleans) -- The cholesterol-lowering drug Lipitor may
also be good for the brain, according to new research that suggests high
doses of the drug can slow the progression of Alzheimer's disease.
The link, says Alzheimer's disease researcher D. Larry Sparks, PhD, is
cholesterol, which serves as fuel for formation of plaque, the waxy
clumps and tangles of protein that are found in the brains of Alzheimer's
disease patients. This plaque, according to Alzheimer's disease
researchers, interferes with brain functioning, destroying memory and
thinking ability.
Lower Cholesterol Stabilizes Alzheimer's Disease
Sparks, who presented his study results at the American Heart
Association's Scientific Sessions 2004, tells WebMD that when "you lower
the cholesterol; you lower the level of beta-amyloid." Beta-amyloid is
the sticky substance that forms the plaque.
In the study, 25 people with early signs of Alzheimer's disease took 80
mg of Lipitor for a year, while 17 with Alzheimer's disease took a
placebo. Those who took Lipitor "had a clear clinical benefit," Sparks
says. He found that their memory and thinking abilities did not decline.
"At minimum, the drug delays entrance to nursing homes; at best, it
improves the quality of a patient's life," he says.
On memory and thinking tests, Alzheimer's disease patients taking Lipitor
showed no change over the 12-month study, while many patients taking a
placebo showed evidence that the disease had progressed.
Overall, 53% of the Alzheimer's disease patients taking Lipitor
stabilized or improved, compared with 28% of patients taking a placebo.
Sparks conducted the study at the Sun Health Research Institute in Sun
City, Ariz., where he is senior scientist and chief of the Roberts
Laboratory for Neurodegenerative Disease Research.
He says initially, Alzheimer's disease patients taking Lipitor were no
different than patients taking a placebo, but "after three months, they
took off. That is when the difference was really apparent."
Lipitor does not enter the brain, so the observed improvements must be
related to decreases in cholesterol levels in the blood, says Sparks.
Sparks theorizes that when the cholesterol levels in the blood go down in
response to treatment, levels of beta-amyloid also decline. This leads to
excess beta-amyloid moving from the brain to the blood, he suggests.
Another possibility is that Lipitor breaks down the beta-amyloid into a
form that is more easily cleared from the body.
That, however, is theory since the only way to really measure amyloid is
to autopsy the brain, William Thies, PhD, vice president of medical and
scientific affairs for the Alzheimer's Association, tells WebMD. "All he
is reporting in this study is clinical results; there is no autopsy
evidence that amyloid in the brain is reduced," says Thies, who wasn't
involved in the study.
Thies says, however, that the results of the new study are promising.
Samuel Gandy, MD, PhD, professor of neurology and director of the Farber
Institute at Thomas Jefferson University in Philadelphia, tells WebMD
Sparks' study is encouraging but preliminary. He says Sparks was the
first researcher to begin pursuing the cholesterol-Alzheimer's link.
"And this is definitely the first clinical trial to report a benefit,"
says Gandy.
He says two other studies of similar cholesterol-lowering drugs are under
way, including a National Institutes of Health study of the drug Zocor,
which not only treats cholesterol in the blood but also enters the brain.
Though Sparks is enthusiastic about his results, he says it is too early
to recommend giving Lipitor or other cholesterol-lowering drugs to
prevent or treat Alzheimer's disease. |
|
| Back to top |
|
 |
Sharon Hope
medicine forum Guru
Joined: 30 Apr 2005
Posts: 752
|
| Posted: Tue May 10, 2005 3:03 am Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
Thank you so much for posting this perfect example of marketing spin for
damage control!
The books, Dr. Graveline's "Lipitor, Thief of Memory", Dr. Cohen's "What you
must know about Statin Drugs & their natural alternatives" and Dr.
Graveline's new book, "Statin Drugs Side Effects and the Misguided War on
Cholesterol" must be gaining attention.
Why else would Pfizer seek national attention for a study of 25 people?
There are over 60 cases of statin **CAUSED** dementia well published in the
medical literature, plus the database of over 10 times that amassed by the
UCSD Statin Study and reported on in a presentation at the International
Coenzyme Q10 Association conference in April.
It is particularly interesting how the Reuter's story ignores the failed
statin Alzheimer's studies.
If Pfizer is stooping to this kind of pathetic marketing spin for damage
control, those books must be finding their audience!
"listener" <listener@nospam.net> wrote in message
news:Xns9651CD56B741Esome1outthere@38.144.126.102...
| Quote: | Nov. 9, 2004 (New Orleans) -- The cholesterol-lowering drug Lipitor may
also be good for the brain, according to new research that suggests high
doses of the drug can slow the progression of Alzheimer's disease.
The link, says Alzheimer's disease researcher D. Larry Sparks, PhD, is
cholesterol, which serves as fuel for formation of plaque, the waxy
clumps and tangles of protein that are found in the brains of Alzheimer's
disease patients. This plaque, according to Alzheimer's disease
researchers, interferes with brain functioning, destroying memory and
thinking ability.
Lower Cholesterol Stabilizes Alzheimer's Disease
Sparks, who presented his study results at the American Heart
Association's Scientific Sessions 2004, tells WebMD that when "you lower
the cholesterol; you lower the level of beta-amyloid." Beta-amyloid is
the sticky substance that forms the plaque.
In the study, 25 people with early signs of Alzheimer's disease took 80
mg of Lipitor for a year, while 17 with Alzheimer's disease took a
placebo. Those who took Lipitor "had a clear clinical benefit," Sparks
says. He found that their memory and thinking abilities did not decline.
"At minimum, the drug delays entrance to nursing homes; at best, it
improves the quality of a patient's life," he says.
On memory and thinking tests, Alzheimer's disease patients taking Lipitor
showed no change over the 12-month study, while many patients taking a
placebo showed evidence that the disease had progressed.
Overall, 53% of the Alzheimer's disease patients taking Lipitor
stabilized or improved, compared with 28% of patients taking a placebo.
Sparks conducted the study at the Sun Health Research Institute in Sun
City, Ariz., where he is senior scientist and chief of the Roberts
Laboratory for Neurodegenerative Disease Research.
He says initially, Alzheimer's disease patients taking Lipitor were no
different than patients taking a placebo, but "after three months, they
took off. That is when the difference was really apparent."
Lipitor does not enter the brain, so the observed improvements must be
related to decreases in cholesterol levels in the blood, says Sparks.
Sparks theorizes that when the cholesterol levels in the blood go down in
response to treatment, levels of beta-amyloid also decline. This leads to
excess beta-amyloid moving from the brain to the blood, he suggests.
Another possibility is that Lipitor breaks down the beta-amyloid into a
form that is more easily cleared from the body.
That, however, is theory since the only way to really measure amyloid is
to autopsy the brain, William Thies, PhD, vice president of medical and
scientific affairs for the Alzheimer's Association, tells WebMD. "All he
is reporting in this study is clinical results; there is no autopsy
evidence that amyloid in the brain is reduced," says Thies, who wasn't
involved in the study.
Thies says, however, that the results of the new study are promising.
Samuel Gandy, MD, PhD, professor of neurology and director of the Farber
Institute at Thomas Jefferson University in Philadelphia, tells WebMD
Sparks' study is encouraging but preliminary. He says Sparks was the
first researcher to begin pursuing the cholesterol-Alzheimer's link.
"And this is definitely the first clinical trial to report a benefit,"
says Gandy.
He says two other studies of similar cholesterol-lowering drugs are under
way, including a National Institutes of Health study of the drug Zocor,
which not only treats cholesterol in the blood but also enters the brain.
Though Sparks is enthusiastic about his results, he says it is too early
to recommend giving Lipitor or other cholesterol-lowering drugs to
prevent or treat Alzheimer's disease.
|
|
|
| Back to top |
|
|
outrider
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1155
|
| Posted: Tue May 10, 2005 4:54 am Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
It wasn't even 25 people taking Lipitor who improved or benefitted.
"...53% of the Alzheimer's disease patients taking Lipitor
stabilized or improved..."
That would be 13.25 patients.
For LISTENER: Great News!
For the reat of the world: Fribble.
Zee |
|
| Back to top |
|
|
Jim Chinnis
medicine forum Guru
Joined: 30 Apr 2005
Posts: 1030
|
| Posted: Wed May 11, 2005 11:17 pm Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
listener <listener@nospam.net> wrote in part:
| Quote: | Lipitor does not enter the brain, so the observed improvements must be
related to decreases in cholesterol levels in the blood, says Sparks.
Sparks theorizes that when the cholesterol levels in the blood go down in
response to treatment, levels of beta-amyloid also decline. This leads to
excess beta-amyloid moving from the brain to the blood, he suggests.
Another possibility is that Lipitor breaks down the beta-amyloid into a
form that is more easily cleared from the body.
|
Huh?
--
Jim Chinnis Warrenton, Virginia, USA |
|
| Back to top |
|
|
Jim Chinnis
medicine forum Guru
Joined: 30 Apr 2005
Posts: 1030
|
| Posted: Wed May 11, 2005 11:35 pm Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
There's also the study by Sparks:
http://tinyurl.com/cop83
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15883262
"RESULTS: Atorvastatin reduced circulating cholesterol levels and
produced a positive signal on each of the clinical outcome
measures compared with placebo. This beneficial effect reached
significance for the Geriatric Depression Scale and the
Alzheimer's Disease Assessment Scale-cognitive subscale at 6
months and was significant at the level of a trend for the
Alzheimer's Disease Assessment Scale-cognitive subscale, Clinical
Global Impression of Change Scale, and Neuropsychiatric Inventory
Scale at 12 months assessed by analysis of covariance with last
observation carried forward. "
--
Jim Chinnis Warrenton, Virginia, USA |
|
| Back to top |
|
|
outrider
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1155
|
| Posted: Wed May 11, 2005 11:50 pm Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
Jim Chinnis wrote:
| Quote: | There's also the study by Sparks:
http://tinyurl.com/cop83
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15883262
"RESULTS: Atorvastatin reduced circulating cholesterol levels and
produced a positive signal on each of the clinical outcome
measures compared with placebo. This beneficial effect reached
significance for the Geriatric Depression Scale and the
Alzheimer's Disease Assessment Scale-cognitive subscale at 6
months and was significant at the level of a trend for the
Alzheimer's Disease Assessment Scale-cognitive subscale, Clinical
Global Impression of Change Scale, and Neuropsychiatric Inventory
Scale at 12 months assessed by analysis of covariance with last
observation carried forward. "
--
Jim Chinnis Warrenton, Virginia, USA
|
In the book Neuropsychology of Cardiovascular disease (Waldstein et al)
Muldoon talks about the probability that different kinds of memory are
affected differently by statins.
Both he and Golomb have one type of memory may be improved while on
statins; and another kind, particularly what we call *working memory*
ie) needed for substantive editing or writing of a dissertation, being
adversely affected.
I hope there will be more money soon for these important possibilities.
Both have merit.
Zee |
|
| Back to top |
|
|
Sharon Hope
medicine forum Guru
Joined: 30 Apr 2005
Posts: 752
|
| Posted: Thu May 12, 2005 12:53 am Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
There is a very important first step in any of these trials, and I have yet
to see it defined:
The researchers must establish a credible, repeatable, definitive test that
differentiates between statin-induced cognitive damage and memory loss, vs
alzheimer's cognitive damage and memory loss.
Unless and until there is that test - the very development and test of which
will benefit hundreds of thousands of patients with both kinds of damage -
there will be very little credibility in the results of those studies.
Yes, as Zee has said, there is the possibility statins can both do harm and
good. My own comparison is the "upper" that works as a depressant in ADD
(formerly 'hyperactive') children.
But until there is a way to reliably and credibly differentiate the statin
damage from the Alzheimer's how can anyone claim to have "improved" the Alz
in some without accounting for having CAUSED statin damage to the cognitive
abilities of other Alz patients?
Also, are they monitoring these study participants AFTER halting the statin,
to see if their cognitive abilities actually IMPROVE after removal of the
statin? That, of course, would show that at least some of the decline was
due to the statin adverse effects, as to my knowledge Alz patients do not
improve.
Another question: What are the ethics involved in administering a drug known
and proven to cause cognitive damage and memory loss to people who suffer
same? How did this study concept pass the ethics test in the first place?
I'm all for working miracles with cognitive recovery. God knows, we have
been chasing a miracle for my husband's recovery from statin/Lipitor-caused
cognitive damage, memory loss, amnesia and aphasia for three years now. And
there is the possibility that unlocking the secrets of Alz recovery might
also benefit those who have statin cognitive damage and memory loss, and
both are very desperately needed.
But I do hope that this is pursued ethically, with caution and in a way that
protects the Alz patient. This is just a situation too easily manipulated
by the industry that brought you so many of the coverups, 'spin' and
diversions with definite patient harm as discussed lately in the news and
the halls of Congress.
Hmmmm.... just think of it... the same people who deny and downplay the
statin adverse cognitive effects producing the test that verifies them as
specific to statins (vs Alz). Don't hold your breath.
"Jim Chinnis" <jchinnis@SPAMalum.mit.edu> wrote in message
news:ljc581lkdeokoe0irhjdmvtjhf4uf4dfal@4ax.com...
| Quote: | There's also the study by Sparks:
http://tinyurl.com/cop83
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15883262
"RESULTS: Atorvastatin reduced circulating cholesterol levels and
produced a positive signal on each of the clinical outcome
measures compared with placebo. This beneficial effect reached
significance for the Geriatric Depression Scale and the
Alzheimer's Disease Assessment Scale-cognitive subscale at 6
months and was significant at the level of a trend for the
Alzheimer's Disease Assessment Scale-cognitive subscale, Clinical
Global Impression of Change Scale, and Neuropsychiatric Inventory
Scale at 12 months assessed by analysis of covariance with last
observation carried forward. "
--
Jim Chinnis Warrenton, Virginia, USA |
|
|
| Back to top |
|
|
Jim Chinnis
medicine forum Guru
Joined: 30 Apr 2005
Posts: 1030
|
| Posted: Thu May 12, 2005 2:14 am Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
"Sharon Hope" <shope@anet.net> wrote in part:
| Quote: | The researchers must establish a credible, repeatable, definitive test that
differentiates between statin-induced cognitive damage and memory loss, vs
alzheimer's cognitive damage and memory loss.
|
That makes a huge assumption that there is a clear difference and
that it can be defined.
| Quote: | Unless and until there is that test - the very development and test of which
will benefit hundreds of thousands of patients with both kinds of damage -
there will be very little credibility in the results of those studies.
Yes, as Zee has said, there is the possibility statins can both do harm and
good. My own comparison is the "upper" that works as a depressant in ADD
(formerly 'hyperactive') children.
But until there is a way to reliably and credibly differentiate the statin
damage from the Alzheimer's how can anyone claim to have "improved" the Alz
in some without accounting for having CAUSED statin damage to the cognitive
abilities of other Alz patients?
|
Only with group statistics. You need a summary measure of
cognitive performance and then a mean a standard deviation, for
instance.
| Quote: | Also, are they monitoring these study participants AFTER halting the statin,
to see if their cognitive abilities actually IMPROVE after removal of the
statin? That, of course, would show that at least some of the decline was
due to the statin adverse effects, as to my knowledge Alz patients do not
improve.
|
I don't follow. You would halt the placebo and statin and give
them all what??? for a few months and then compare the groups to
see if what???
--
Jim Chinnis Warrenton, Virginia, USA |
|
| Back to top |
|
|
Sharon Hope
medicine forum Guru
Joined: 30 Apr 2005
Posts: 752
|
| Posted: Fri May 13, 2005 4:20 am Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
"Jim Chinnis" <jchinnis@SPAMalum.mit.edu> wrote in message
news:9ql581l9beud7h02ap3jdjdkl56fdpk8vg@4ax.com...
| Quote: | "Sharon Hope" <shope@anet.net> wrote in part:
The researchers must establish a credible, repeatable, definitive test
that
differentiates between statin-induced cognitive damage and memory loss, vs
alzheimer's cognitive damage and memory loss.
That makes a huge assumption that there is a clear difference and
that it can be defined.
|
Alzheimer's is fatal. Statin cognitive damage and memory loss, while
functionally similar to Alz, is typically not if the statin is halted
(barring in this observation the other statin adverse effects that can be
fatal, such as rhabdo or other statin damage to kidney and/or liver, etc.)
Also, the amyloid plaque doesn't show up on MRI or PET in a statin dementia,
to my knowledge.
| Quote: | Unless and until there is that test - the very development and test of
which
will benefit hundreds of thousands of patients with both kinds of damage -
there will be very little credibility in the results of those studies.
Yes, as Zee has said, there is the possibility statins can both do harm
and
good. My own comparison is the "upper" that works as a depressant in ADD
(formerly 'hyperactive') children.
But until there is a way to reliably and credibly differentiate the statin
damage from the Alzheimer's how can anyone claim to have "improved" the
Alz
in some without accounting for having CAUSED statin damage to the
cognitive
abilities of other Alz patients?
Only with group statistics. You need a summary measure of
cognitive performance and then a mean a standard deviation, for
instance.
Also, are they monitoring these study participants AFTER halting the
statin,
to see if their cognitive abilities actually IMPROVE after removal of the
statin? That, of course, would show that at least some of the decline was
due to the statin adverse effects, as to my knowledge Alz patients do not
improve.
I don't follow. You would halt the placebo and statin and give
them all what??? for a few months and then compare the groups to
see if what???
|
The idea would be to follow the statin group past the the end of the statin
treatment phase of the trial, and look for improvement in cognitive ability
after the statin.
This would of course be much more difficult in the trial we are discussing,
because all the participants had Alz, so some degredation would be expected
over time due to the Alz.
However, it is not implausible that some (15%-40%) of the statin takers
would have statin cognitive damage. The Alz might arrest, but I don't know
of it improving. If the Alz patient improved subsequent to the statin
(e,g., retest every 6 months for 2 years), it would be indicative of the
statin doing harm - but masked by the Alz.
Dr. Graveline, in his book "Lipitor, Thief of Memory" depicts a hypothetical
elderly patient whose statin-caused memory loss and confusion is
misdiagnosed as Alz, and the pathetic irony of the statins being continued
to keep the heart healthy despite the failing cognition. But all the while
the cognitive damage is actually due to the statin.
This study is hauntingly close to that scenario.
| Quote: | --
Jim Chinnis Warrenton, Virginia, USA |
|
|
| Back to top |
|
|
Jim Chinnis
medicine forum Guru
Joined: 30 Apr 2005
Posts: 1030
|
| Posted: Fri May 13, 2005 11:47 pm Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
"Sharon Hope" <shope@anet.net> wrote in part:
| Quote: |
"Jim Chinnis" <jchinnis@SPAMalum.mit.edu> wrote in message
news:9ql581l9beud7h02ap3jdjdkl56fdpk8vg@4ax.com...
"Sharon Hope" <shope@anet.net> wrote in part:
The researchers must establish a credible, repeatable, definitive test
that
differentiates between statin-induced cognitive damage and memory loss, vs
alzheimer's cognitive damage and memory loss.
That makes a huge assumption that there is a clear difference and
that it can be defined.
Alzheimer's is fatal. Statin cognitive damage and memory loss, while
functionally similar to Alz, is typically not if the statin is halted
(barring in this observation the other statin adverse effects that can be
fatal, such as rhabdo or other statin damage to kidney and/or liver, etc.)
Also, the amyloid plaque doesn't show up on MRI or PET in a statin dementia,
to my knowledge.
|
They all had Alzheimers.
| Quote: | Unless and until there is that test - the very development and test of
which
will benefit hundreds of thousands of patients with both kinds of damage -
there will be very little credibility in the results of those studies.
Yes, as Zee has said, there is the possibility statins can both do harm
and
good. My own comparison is the "upper" that works as a depressant in ADD
(formerly 'hyperactive') children.
But until there is a way to reliably and credibly differentiate the statin
damage from the Alzheimer's how can anyone claim to have "improved" the
Alz
in some without accounting for having CAUSED statin damage to the
cognitive
abilities of other Alz patients?
Only with group statistics. You need a summary measure of
cognitive performance and then a mean a standard deviation, for
instance.
Also, are they monitoring these study participants AFTER halting the
statin,
to see if their cognitive abilities actually IMPROVE after removal of the
statin? That, of course, would show that at least some of the decline was
due to the statin adverse effects, as to my knowledge Alz patients do not
improve.
I don't follow. You would halt the placebo and statin and give
them all what??? for a few months and then compare the groups to
see if what???
The idea would be to follow the statin group past the the end of the statin
treatment phase of the trial, and look for improvement in cognitive ability
after the statin.
This would of course be much more difficult in the trial we are discussing,
because all the participants had Alz, so some degredation would be expected
over time due to the Alz.
However, it is not implausible that some (15%-40%) of the statin takers
would have statin cognitive damage. The Alz might arrest, but I don't know
of it improving. If the Alz patient improved subsequent to the statin
(e,g., retest every 6 months for 2 years), it would be indicative of the
statin doing harm - but masked by the Alz.
Dr. Graveline, in his book "Lipitor, Thief of Memory" depicts a hypothetical
elderly patient whose statin-caused memory loss and confusion is
misdiagnosed as Alz, and the pathetic irony of the statins being continued
to keep the heart healthy despite the failing cognition. But all the while
the cognitive damage is actually due to the statin.
This study is hauntingly close to that scenario.
|
These people were diagnosed with Alz. Then some were given
statins. The statin group got better than the ones given a
placebo. I don't follow your argument.
--
Jim Chinnis Warrenton, Virginia, USA |
|
| Back to top |
|
|
Guest
|
| Posted: Sat May 14, 2005 3:07 am Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
Sharon Hope wrote:
| Quote: | However, it is not implausible that some (15%-40%) of the statin
takers
would have statin cognitive damage.
|
There are millions of people taking statins. Is it plausable to
suggest that there are hundreds of thousands of people with statin
cognitive damage? |
|
| Back to top |
|
|
elgoog
medicine forum Guru
Joined: 28 Apr 2005
Posts: 412
|
| Posted: Sat May 14, 2005 11:58 am Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
tonywes...@gmail.com wrote:
| Quote: | Sharon Hope wrote:
However, it is not implausible that some (15%-40%) of the statin
takers
would have statin cognitive damage.
There are millions of people taking statins. Is it plausable to
suggest that there are hundreds of thousands of people with statin
cognitive damage?
|
Why not? 15 to 40 percent of congress suffers from cognitive damage
(and I don't think they're even on statins).  |
|
| Back to top |
|
|
Susan
medicine forum Guru
Joined: 05 May 2005
Posts: 932
|
| Posted: Sat May 14, 2005 1:25 pm Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
x-no-archive: yes
tonywesley@gmail.com wrote:
| Quote: | Sharon Hope wrote:
However, it is not implausible that some (15%-40%) of the statin
takers
would have statin cognitive damage.
There are millions of people taking statins. Is it plausable to
suggest that there are hundreds of thousands of people with statin
cognitive damage?
|
It is plausible, particularly given how vague and subtle some cognitive
damage can be. Doctors' all-too-common standard response to such
complaints is that it's a part of aging, too easy a conclusion to leap
to in the age group typically taking the drug.
Susan |
|
| Back to top |
|
|
outrider
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1155
|
| Posted: Sat May 14, 2005 3:22 pm Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
Susan wrote:
| Quote: | x-no-archive: yes
tonywesley@gmail.com wrote:
Sharon Hope wrote:
However, it is not implausible that some (15%-40%) of the statin
takers
would have statin cognitive damage.
There are millions of people taking statins. Is it plausable to
suggest that there are hundreds of thousands of people with statin
cognitive damage?
It is plausible, particularly given how vague and subtle some
cognitive
damage can be. Doctors' all-too-common standard response to such
complaints is that it's a part of aging, too easy a conclusion to
leap
to in the age group typically taking the drug.
Susan
|
Quite true Susan. The statin injured hear such comments frequently from
their physicians. It is often only when family members or friends
become alarmed and substantiate what the affected person is saying that
the reports are given validity. This happens out in the world at large
too. A family member or other advocate for the statin injured is given
validity, while the statin injured are dismissed as not having all
their marbles, or shat upon in any number of other less obvious ways.
It is all very puzzling that today, in our society, people will still
*use* someone who is disabled for their own ends.
Zee |
|
| Back to top |
|
|
outrider
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1155
|
| Posted: Sat May 14, 2005 8:56 pm Post subject:
Re: Cholesterol Drug May Slow Alzheimer's Disease
|
|
|
elgoog wrote:
| Quote: | tonywes...@gmail.com wrote:
Sharon Hope wrote:
However, it is not implausible that some (15%-40%) of the statin
takers
would have statin cognitive damage.
There are millions of people taking statins. Is it plausable to
suggest that there are hundreds of thousands of people with statin
cognitive damage?
Why not? 15 to 40 percent of congress suffers from cognitive damage
(and I don't think they're even on statins).
|
I'm not that familiar with the members of the U.S. congress Elgoog but
some of the major players are all on statins: Bush, Cheney, and
Clinton.
I think a higher percentage of world leaders may be on statins than the
general population. Current guidelines suggest middle aged males with
an ldl cholesterol level over 100 (and perhaps overweight and under
stress) should be medicated.
If you were Cheney's physician would you not recommend statins to him?
You would surely not want it said you had not provided "standard of
care" for one of your nation's pre-eminent citizens.
So. Back to statin induced cognitive impairment....
Zee |
|
| Back to top |
|
|
Google
|
|
| Back to top |
|
|
|
|
The time now is Sat Nov 22, 2008 12:22 am | All times are GMT
|
|
Personal Loans | Remortgages | Houses for Sale | Loans | Auto Loans
|
|
Copyright © 2004-2005 DeniX Solutions SRL
|
|
Other DeniX Solutions sites:
electronics forum,
Science forum
Unix/Linux blog
Unix/Linux documentation
Unix/Linux forums
|
Powered by phpBB © 2001, 2005 phpBB Group
|
|
FAQ
Search
Memberlist
Usergroups
Register
Profile
Log in to check your private messages
Log in
Forum index
»
Medicine forums
»
cardiology
