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Other metal chelation therapeutics
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PostPosted: Sun Jul 31, 2005 4:54 pm    Post subject: Other metal chelation therapeutics Reply with quote

Nanoparticle and other metal chelation therapeutics in Alzheimer
Liu G, Garrett MR, Men P, Zhu X, Perry G, Smith MA
Biochim Biophys Acta. 2005 Jul 26;

Current therapies for Alzheimer disease (AD) such as the
anticholinesterase inhibitors and the latest NMDA receptor inhibitor,
Namenda, provide moderate symptomatic delay at various stages of
disease, but do not arrest disease progression or supply meaningful
remission. As such, new approaches to disease management are urgently
needed. Although the etiology of AD is largely unknown, oxidative
damage mediated by metals is likely a significant contributor since
metals such as iron, aluminum, zinc, and copper are dysregulated and/or
increased in AD brain tissue and create a pro-oxidative environment.
This role of metal ion-induced free radical formation in AD makes
chelation therapy an attractive means of dampening the oxidative stress
burden in neurons. The chelator desferioxamine, FDA approved for iron
overload, has shown some benefit in AD, but like many chelators, it has
a host of adverse effects and substantial obstacles for tissue-specific
targeting. Other chelators are under development and have shown various
strengths and weaknesses. In this review, we propose a novel system of
chelation therapy through the use of nanoparticles. Nanoparticles
conjugated to chelators show a unique ability to cross the blood-brain
barrier (BBB), chelate metals, and exit through the BBB with their
corresponding complexed metal ions. This method may prove to be a safe
and effective means of reducing the metal load in neural tissue thus
staving off the harmful effects of oxidative damage and its sequelae.

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