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 Posted: Sat Jul 02, 2005 7:44 pm Post subject:
Pregnancy and d-dimer
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What is the relationship (if any) between pregnancy and the d-dimer
test for DVT? |
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Robert
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1700
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| Posted: Sat Jul 02, 2005 7:55 pm Post subject:
Re: Pregnancy and d-dimer
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<talitakasselman@hotmail.com> wrote in message
news:1120340690.158705.238710@o13g2000cwo.googlegroups.com...
| Quote: | What is the relationship (if any) between pregnancy and the d-dimer
test for DVT?
|
Eur J Obstet Gynecol Reprod Biol. 2005 Apr 1;119(2):185-8. Related Articles,
Books, LinkOut
Changes in haemostasis during normal pregnancy.
Uchikova EH, Ledjev II.
Department of Obstetrics and Gynecology, Higher Medical Institute, Plovdiv
Bul.Konstantin, Velichkov 9, Plovdiv, Bulgaria.
ekaterinauchikova@Yahoo.com.au
OBJECTIVES: (1) To study the changes in the haemostatic variables during
normal pregnancy, and (2) to compare them with the corresponding variables
in a control group of nonpregnant women. SETTING: University Hospital.
SUBJECTS: The study involves two groups of women: pregnant women (in
35th-40th gestational weeks (GW)) (N = 35) and a control group of
nonpregnant women (N = 35). METHODS: We examined the global tests, the
variables relating to coagulation and fibrinolysis and the group of natural
inhibitors of coagulation, and compared them between the two groups.
RESULTS: The pregnant women had statistically significantly higher values
for: prothrombin time (PT) (P < 0.0001), thrombin time (TT) (P < 0.0001),
fibrinogen (P < 0.0001), activity of factor VII (P < 0.0001), factor X (P <
0.0001) and alpha2-antiplasmin (P < 0.002), plasma concentration of D-dimer
(plsDD) (P < 0.0001) and activity of heparin cofactor II (HCII) (P < 0.002).
They had statistically significantly lower activity of protein C (PrC) (P <
0.0001) and of total protein S (TPrS) (P < 0.0001). CONCLUSION: During
normal pregnancy the activation of coagulation is counterbalanced by the
activation of fibrinolysis, which maintains the haemostatic balance.
PMID: 15808377 [PubMed - in process] |
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Manky Badger
medicine forum Guru Wannabe
Joined: 01 May 2005
Posts: 158
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| Posted: Sat Jul 02, 2005 8:16 pm Post subject:
Re: Pregnancy and d-dimer
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<talitakasselman@hotmail.com> wrote in message
news:1120340690.158705.238710@o13g2000cwo.googlegroups.com...
| Quote: | What is the relationship (if any) between pregnancy and the d-dimer
test for DVT?
|
I HATE the phrase "d-dimer test for DVT" - it is SO misleading !!!
The common misconception is that if the d-dimer is raised it is indicative
of a DVT, therefore if the d-dimer is not raised, then the patient has no
DVT. Which is not always the case.
I particularly dislike the card kits which have a lower level of detection
of about 250 megaparsecs per ml ?? - (can't remember the units) when the
actual lower limit of a positive result is often considered to be in the
range 100 - 200. |
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Robert
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1700
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| Posted: Sun Jul 03, 2005 1:41 am Post subject:
Re: Pregnancy and d-dimer
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"Manky Badger" <spam@puritanDOTfreeserve.FULLSTOPcoSPOTuk> wrote in message
news:da73n9$g78$1@news6.svr.pol.co.uk...
| Quote: |
talitakasselman@hotmail.com> wrote in message
news:1120340690.158705.238710@o13g2000cwo.googlegroups.com...
What is the relationship (if any) between pregnancy and the d-dimer
test for DVT?
I HATE the phrase "d-dimer test for DVT" - it is SO misleading !!!
The common misconception is that if the d-dimer is raised it is indicative
of a DVT, therefore if the d-dimer is not raised, then the patient has no
DVT. Which is not always the case.
I particularly dislike the card kits which have a lower level of detection
of about 250 megaparsecs per ml ?? - (can't remember the units) when the
actual lower limit of a positive result is often considered to be in the
range 100 - 200.
|
I really didn't know what he was getting at with that question. Which is why
I posted that other citation first.
We are switching out D dimers from Sysmex coag machine to the Abbott
Architech multi chemistry immunology analyzer.
Rev Med Suisse. 2005 Jan 26;1(4):283, 286-9. Related Articles, Books,
LinkOut
[Diagnosis of suspected deep venous thrombosis and pulmonary embolism during
pregnancy]
[Article in French]
Righini M, Bounameaux H.
Service d'angiologie et d'hemostase, Hopital Universitaire de Geneve, 1211
Geneve 14. Marc.Righini@hcuge.ch
Venous thromboembolic disease (VTE) is a frequent clinical problem during
pregnancy and post-partum. Pulmonary embolism (PE) remains the most common
cause of mortality during pregnancy and post-partum in western countries. In
the majority of cases, DVT may be diagnosed by non-invasive tests such as
clinical probability, D-dimer measurement and venous compression
ultrasonography. In contrast, at least one irradiating invasive exam is
necessary in suspected PE. The lung scan, the most validated diagnostic test
for PE during pregnancy and fetal irradiation is quite low, in particular if
only perfusion lung scan is used. Helical computed tomography (hCT) has
widely replaced lung scan in the diagnostic approach of suspected pulmonary
embolism. However, it has never been validated in pregnant women.
Publication Types:
Review
Review, Tutorial
PMID: 15771357 [PubMed - indexed for MEDLINE] |
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Manky Badger
medicine forum Guru Wannabe
Joined: 01 May 2005
Posts: 158
|
| Posted: Sun Jul 03, 2005 7:16 am Post subject:
Re: Pregnancy and d-dimer
|
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"Robert" <Robertitsme@hotmail.com> wrote in message
news:HKSdneaMj8cJw1rfRVn-qA@got.net...
| Quote: |
"Manky Badger" <spam@puritanDOTfreeserve.FULLSTOPcoSPOTuk> wrote in
message
news:da73n9$g78$1@news6.svr.pol.co.uk...
talitakasselman@hotmail.com> wrote in message
news:1120340690.158705.238710@o13g2000cwo.googlegroups.com...
What is the relationship (if any) between pregnancy and the d-dimer
test for DVT?
I HATE the phrase "d-dimer test for DVT" - it is SO misleading !!!
The common misconception is that if the d-dimer is raised it is
indicative
of a DVT, therefore if the d-dimer is not raised, then the patient has no
DVT. Which is not always the case.
I particularly dislike the card kits which have a lower level of
detection
of about 250 megaparsecs per ml ?? - (can't remember the units) when the
actual lower limit of a positive result is often considered to be in the
range 100 - 200.
I really didn't know what he was getting at with that question. Which is
why
I posted that other citation first.
We are switching out D dimers from Sysmex coag machine to the Abbott
Architech multi chemistry immunology analyzer.
|
Interesting......
We've been promised d-dimers on our CA 7000 for a couple of years, but we're
still struggling to do them. |
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