Oxidative damage / endometriosis

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Ann N Y Acad Sci. 2005 May;1042:186-94. Related Articles, Links

Oxidative damage and mitochondrial DNA mutations with endometriosis.

Kao SH, Huang HC, Hsieh RH, Chen SC, Tsai MC, Tzeng CR.

Department of Obstetrics and Gynecology, Taipei Medical University,
250, Wu-Hsing Street, Taipei 110, Taiwan. kaosh@tmu.edu.tw.

Endometriosis, a frequently encountered disease in gynecology, is a
considerable threat to the physical, psychological, and social
integrity of women. Moreover, up to 50% of infertile patients have this
disease. The etiology and pathogenesis of this important disease are
poorly understood; it is defined as an ectopic location for
endometrium-like glandular epithelium and stroma outside of the uterine
cavity. It still remains an open question as to what extent the
peritoneal environment influences the establishment and/or progression
of endometriosis. As a result of such stress, a sterile, inflammatory
reaction with the secretion of growth factors, cytokines, and
chemokines is generated, which is especially deleterious to successful
reproduction. Significantly higher amounts of oxidative damage were
detected in endometriotic lesions than in controlled normal
endometrium, including mitochondrial DNA (mtDNA) rearrangement,
8-OH-deoxyguanosine (8-OH-dG), and lipoperoxide contents. There were
approximately sixfold increases in 8-OH-dG and lipoperoxides in
chocolate cysts compared with normal endometrial tissues. A novel
5,335-bp deletion of mtDNA was identified in endometriotic tissue.
According to these results, we propose that oxidative stress and mtDNA
mutations might be anticipated in the initiation or progression of
endometriosis. Only by understanding the mechanisms involved in the
pathogenesis of endometriosis can we develop a basis for new diagnostic
and therapeutic approaches.

PMID: 15965062 [PubMed - in process]

Iron overload in the peritoneal cavity of women with pelvic
endometriosis.

Van Langendonckt A, Casanas-Roux F, Donnez J.

Department of Gynecology, Universite Catholique de Louvain, Brussels,
Belgium.

OBJECTIVE: To examine the possible involvement of iron in the
physiopathology of endometriosis. DESIGN: Prospective study. SETTING:
Department of gynecology in a university hospital. PATIENT(S): Seventy
patients undergoing laparoscopy. INTERVENTION(S): Collection of
peritoneal fluid (n = 57), blood samples, and biopsy samples from
endometrium (n = 62) and from endometriotic (n = 33) and
normal-appearing peritoneum (n = 53). MAIN OUTCOME MEASURE(S):
Measurement of iron and ferritin in serum and peritoneal fluid and
staining of iron deposits with Prussian blue in tissues. RESULT(S):
Iron and ferritin concentrations were significantly higher in the
peritoneal fluid of patients with endometriosis compared with controls
during the secretory phase. Higher rates of ferritin and hemosiderin
deposits were observed in the peritoneum adjacent to red (100%), black
(57%), and white (62%) lesions compared with normal-appearing
peritoneum (25%). Deposits were more frequent during the secretory
phase than the proliferative phase in healthy peritoneum from controls,
whereas they were found throughout the cycle in the vicinity of lesions
in patients with endometriosis. Similar rates of iron deposition were
observed in the stroma of black and white lesions and in eutopic
endometrium from patients with endometriosis. CONCLUSION(S): Iron
overload was observed in the cellular and peritoneal fluid compartments
of the peritoneal cavity of women with endometriosis. Iron deposits
seem to be related to the presence of lesions, suggesting that iron may
be involved in the pathogenesis of endometriosis. Fertil Steril. 2002
Oct

PMID: 12372445 [PubMed - indexed for MEDLINE]

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