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Forum index » Medicine forums » pharmacy
Stability Ampho in water
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P T
medicine forum addict


Joined: 29 Apr 2005
Posts: 67

PostPosted: Fri Apr 29, 2005 12:41 pm    Post subject: Stability Ampho in water Reply with quote
Had an rx for amphotericin in water for a long term nasal irrigation.
The problem is that we could only find reference to a 7 day stability.
I'm not even sure if that IS for a compound, or for parenteral
preparations. Does anyone know if the solution keeps longer?
(Refrigerated, of course.)
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Dr. Wayne Simon
medicine forum Guru Wannabe


Joined: 30 Apr 2005
Posts: 111

PostPosted: Sat Apr 30, 2005 4:15 am    Post subject: Re: Stability Ampho in water Reply with quote
"P T" <Petepenguin@webtv.net> wrote in message
news:26372-4272478C-174@storefull-3132.bay.webtv.net...
Quote:
Had an rx for amphotericin in water for a long term nasal irrigation.
The problem is that we could only find reference to a 7 day stability.
I'm not even sure if that IS for a compound, or for parenteral
preparations. Does anyone know if the solution keeps longer?
(Refrigerated, of course.)

Its a colloidal solution. It is more stable in the lower pH of D5W. It is
also more stable when protected from sunlight. I don't know the actual
stability, and it depends on the concentration, but my guess is at a week
out, you probably do not have enough concentration remaining active to meet
reasonable standards. I may be wrong. I suggest measuring the active
concentration at time initial, and at given intervals throughout a week or
so. Of course also in a light protected container.
>
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