Questions: Angiogenesis in Cancer

Kumar · medicine forum Guru Joined: 10 May 2005 Posts: 870

Hello,

I have following thoughts about Angiogenesis & request you to awnser
these after serious thinking:-

When cancer is in tumor stage it is considered that cancer cell can
encourage Angiogenesis for their nutrition, multiplication & spread.
But, I think that there can be two conditions related to it.

1.On naturally improved/biologically medicated immunity:- when a person
gets cancer, our immune system should be trying to kill/correct the
cabcer cells. But when our immune system couldn't handle these due to
required immune strength, cancer cells then may opt to arrest/encapsule
these in tumor etc.in cansiderations of (a)to starve them by inhibiting
blood supply or their respiration or nutrients (b)to restrict & resist
there growth & spread (c)to hold them in encapsuled/tumor state &
pursue to improve the immunity or wait for right time/immunity level,
when it can handle/kill thise cancer cells.

2.On weakening of immunity (natural or otherwise):- It may encourage
cancer cells to multiply & spread as progress of disease. I can't say
whether it can be Angiogenesis oriented or not?

Now my questions are:

1.Are cancer cells or other disease causing agents in tumor/latencies
capable of encouraging Angiogenesis, in view of that it os our body's
immune defence mechanism?

2. Can it be thought/possible that Angiogenesis is an immune defence
mechanism "On naturally improved/biologically medicated immunity" as I
described above, either to transport immune agents in tumor to kill
them OR to encourage them to resurface/take out from tumor for exposure
to immune system for killing them?

3. Can it be also thought that Angiogenesis may not be possible "On
weakening of immunity (natural or otherwise)" as I described above?

In short, can it be dynamically thought that, somewhat spread or
resurfacing of cancer cells & Angiogenesis can occur on improved
immunity to kill those as a "direction towords cure" instead of
"direction towords progress of disease"? This aspects may also be
thought for other latencies.

Best wishes & regards.

Kumar · medicine forum Guru Joined: 10 May 2005 Posts: 870

I think it is nowhere mentioned in detail that, what happens when a
person aquire any latent infection or cancer and his immune streangth
is substancially improved, naturally at some later date? Can this
strengthend immune system handle & cure latent infections & cancer?

Steph · medicine forum Guru Joined: 03 May 2005 Posts: 504

"kumar" <lordshiva5753@rediffmail.com> wrote in message
news:1119155244.782048.49380@f14g2000cwb.googlegroups.com...

Kumar · medicine forum Guru Joined: 10 May 2005 Posts: 870

??

Let me make my questions/thoughts bit clear:-

There can be two conditions for which I want to know as under:-

1. When angiogenic growth factors are produced in excess of
angiogenesis inhibitors (may be under presence of strong/suitable
immune response):-

Can Angiogenesis be immune system oriented & meant for transmission of
immune defence agents in tumor to kill cancer cells within tumor when
immune system is being strengthened-naturally or medicated?
OR
Can Angiogenesis be meant to encourage cancer cell to come out of tumor
& exposed to immune system to handle them by it, in case of immune
system is being strengthened-natural or medicated?

2.When inhibitors are present in excess of stimulators (may be under
weak immune response, pursued by cancer cells or weak surrounded
tissues):-

Will Angiogenesis be cancer cell/surrounded weak tissue's oriented,
which will aid to cancer progression & spread?

Are angiogenic growth factors and angiogenesis inhibitors are
tissue/cancer specific & if can these be measured in lab?

I think Angiogenesis is not considered as a part of immune
respose/system but It should be. I also think that, it is not yet
suitably documented/researched about, what happens to tumors & other
latencies on immune system is being naturally strengthened?

Being important & dynamic thoughts, I request you to reply to above
questions after deep thinking.

Ref:

Angiogenesis: http://www.angio.org/understanding/understanding.html

The immune system
system:http://www.cancerhelp.org.uk/help/default.asp?page=118

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