Statins, low cholesterol and haemorrhagic stroke

Sharon Hope · medicine forum Guru Joined: 30 Apr 2005 Posts: 752

http://bmj.bmjjournals.com/cgi/eletters/333/7557/22

British Medical Journal discussion on low cholesterol and haemorrhagic
stroke.

But those who read the Lipitor Prescribing Information published by Pfizer,
as approved by the FDA, are already aware of the relationship between low
cholesterol and haemorrhagic stroke (and other haemorrhagic conditions):

Lipitor Prescribing Information
http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop?_nfpb=true&_pageLabel=prescribingInformation

Pfizer states:

CNS Toxicity
Brain hemorrhage was seen in a female dog treated for 3 months at 120
mg/kg/day. Brain hemorrhage and optic nerve vacuolation were seen in another
female dog that was sacrificed in moribund condition after 11 weeks of
escalating doses up to 280 mg/kg/day.

....

CNS vascular lesions, characterized by perivascular hemorrhages, edema, and
mononuclear cell infiltration of perivascular spaces, have been observed in
dogs treated with other members of this class.

and in humans Pfizer states:

Digestive System: ... rectal hemorrhage...gum hemorrhage

Urogenital System: ...vaginal hemorrhage...uterine hemorrhage

Special Senses:...eye hemorrhage

When you think about it, it makes sense that there is a relationship. The
arteries are a high-pressure system. When there is a weakness in the wall
of this high-pressure line, usually due to inflammation, the body applies a
pressure patch, made of cholesterol. When the patching material is not
available sufficient to protect the wall of the high pressure system, there
is a blow-out.

listener · medicine forum Guru Joined: 05 May 2005 Posts: 617

"Sharon Hope" <shope@anet.net> wrote in news:S-
qdneWoE4hIliTZnZ2dnUVZ_rqdnZ2d@comcast.com:

Google