Iron / excess angiogenesis

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Cutaneous wound healing is impaired in hemophilia B.
Hoffman M, Harger A, Lenkowski A, Hedner U, Roberts HR, Monroe DM
Blood. 2006 Jul 6;

We used a mouse model to test the hypothesis that the time course and
histology of wound healing is altered in hemophilia B. Three mm punch
biopsies were placed in the skin of normal and hemophilic mice. The
size of the wounds was measured daily until the epidermal defect
closed. All wounds closed in hemophilic mice by 12 days, compared to 10
days in normal animals. Skin from the area of the wound was harvested
at different time points and examined histologically. Hemophilic, but
not normal animals, developed subcutaneous hematomas. Macrophage
infiltration was significantly delayed in hemophilia B. Unexpectedly,
hemophilic mice developed twice as many blood vessels in the healing
wounds as controls, and the increased vascularity persisted for at
least two weeks. The deposition and persistence of ferric iron was also
greater in hemophilic mice. We hypothesize that iron plays a role in
promoting excess angiogenesis after wounding as it had been proposed to
do in hemophilic arthropathy. We have demonstrated that impaired
coagulation leads to delayed wound healing with abnormal histology. Our
findings have significant implications for treatment of hemophiliacs,
and also highlight the importance of rapidly establishing hemostasis
following trauma or surgery.

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