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Joined: 28 Apr 2005
|Posted: Wed Jul 05, 2006 1:34 am Post subject:
Lowering the amount of iron in the body
Iron Depletion Therapy for Type 2 DM and NAFLD
This study is currently recruiting patients.
Verified by National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK) March 2006
Researchers determine that multiple sclerosis and diabetes are
closely linked diseases
March 21, 2001
TORONTO, March 20 /CNW/ via NewsEdge Corporation -
A team of researchers led by Hospital for Sick Children (HSC) senior
scientist Michael Dosch has determined that multiple sclerosis and
type I (juvenile) diabetes mellitus are far more closely linked than
previously thought, including the role cow milk protein plays as a
risk factor in the development of both diseases for people who are
genetically susceptible. This research is published in recent issues
of The Journal of Immunology (April 1 and February 15, 2001).
Multiple sclerosis (MS) and type I diabetes mellitus are autoimmune
disorders, where the body's immune system attacks its own tissue. The
diseases are entirely different clinically, but have nearly identical
ethnic and geographic distribution, genetic similarities, and, as is
now known, shared environmental risk factors.
In a collaboration between The Hospital For Sick Children, St.
Michael's Hospital and the Pittsburgh Children's Hospital, Dr.
Dosch's laboratory discovered a high degree of similarity in the
autoimmunity of MS and diabetes patients, and that a widely used
mouse model for diabetes could also develop an MS-like disease.
"Much to our surprise, we found that immunologically, type I diabetes
and multiple sclerosis are almost the same - in a test tube you can
barely tell the two diseases apart," said Dr. Dosch, the study's
principal investigator, a senior scientist in the HSC Research
Institute, and a professor of Paediatrics and Immunology at the
University of Toronto (U of T). "We found that the autoimmunity was
not specific to the organ system affected by the disease. Previously
it was thought that in MS autoimmunity would develop in the central
nervous system, and in diabetes it would only be found in the
pancreas. We found that both tissues are targeted in each disease."
In diabetes and MS, there is a long, drawn-out period of silent
disease years before the appearance of symptoms and diagnosis of the
disease. In diabetes, it is this "pre-diabetes" phase that is
targeted by interventions to stop the development of the full-blown
disease. Similar efforts are planned for individuals at high risk for
"We are planning a large international study with centres in Canada
and the US to test the possibility of interventions during the pre-MS
phase," added Dr. Dosch.
One of the major environmental risk factors for diabetes is exposure
to cow milk protein. Based on the role of cow milk protein as a risk
factor in the development of type I diabetes, an international global
diabetes prevention trial called TRIGR - Trial to Reduce
Insulin-dependent diabetes in the Genetically at Risk - is expected
to begin later this year, with Dr. Dosch as the trial's basic science
chair. In the first step to test just how far the similarities
between MS and diabetes go, the study's researchers looked for signs
of abnormal immunity to cow milk in MS patients. Such abnormalities
were indeed found in most patients, suggesting that similar processes
may contribute to both diseases. If confirmed in a larger and
prospective family study, it may become possible to design dietary
means to influence the course of MS as well as diabetes.
"The similarities found between MS and type I diabetes will open new
avenues of research. Our next focus will be to study MS family
members for signs of early MS," said Dr. Paul O'Connor, head of the
MS clinic at St. Michael's Hospital, a co-author of the study and
Associate Professor of Neurology at U of T.
Other collaborators on this research were: Shawn Winer, Igor
Astsaturov, Roy K. Cheung, Lakshman Gunaratnam, Denise D. Wood and
Professor Mario Moscarello, all from the HSC Research Institute;
Colin McKerlie, Sunnybrook and Women's Health Sciences Centre and the
University of Toronto; and Professor Dorothy J. Becker, Children's
Hospital of Pittsburgh and the University of Pittsburgh.
Funding for this research was provided by the Canadian Institutes of
Health Research, the Juvenile Diabetes Foundation, the Canadian
Diabetes Association, the US National Institutes of Health and the
/For further information: please contact: Laura Greer, Public
Affairs, The Hospital for Sick Children, (416) 813-5046,
laura.greer(at)sickkids.ca; Tracy MacIsaac, Media Relations, St.
Michael's Hospital, (416) 864-5047,macisaact(at)smh.toronto.on.ca
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