Obsessive-compulsive disorder / oxidative stress

ironjustice@aol.com · medicine forum Guru Joined: 28 Apr 2005 Posts: 1522

Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume 30, Issue 6 , 30 August 2006, Pages 1039-1042
..
Examination of free radical metabolism and antioxidant defence system
elements in patients with obsessive-compulsive disorder

Serpil Ersana, Sevtap Bakirb, E. Erdal Ersanc and Orhan Dogand, , ,

aDepartment of Chemistry Engineering, Engineering Faculty, Cumhuriyet
University, Sivas, Turkey
bDepartment of Biochemistry, Medical Faculty, Cumhuriyet University,
Sivas, Turkey
cState Hospital, Sivas, Turkey
dDepartment of Psychiatry, Medical Faculty, Cumhuriyet University,
Sivas, Turkey

Available online 8 May 2006.

Abstract
Free radicals and oxidative stress are involved in the pathogenesis of
various diseases. Malondialdehyde (MDA) is a natural product of lipid
peroxidation in all mammalian cells. Vitamins C and E are nonenzymatic
antioxidant structures. Our study investigated the role of free
radicals in the obsessive-compulsive disorder (OCD). The participants
were 30 patients with OCD that were drug-free at least for a month and
a control group of 30 healthy subjects, matched with respect to age and
sex. In both groups, the levels of erythrocyte malondialdehyde and the
plasma vitamin C and E concentrations were measured. The levels of
malondialdehyde were significantly higher in the patient group than in
the control group (p < .01). The levels of plasma vitamin E were
significantly lower in the patient than in the control group (p < .02).
Although our patient group had slightly lower concentrations of plasma
vitamin C compared to our control group, the difference between these
two groups was not statistically significant. There was a significant
correlation between increasing malondialdehyde levels and decreasing
vitamin E concentrations. This study shows the presence of a
significant relationship of OCD and oxidative stress, and consequently,
an involvement of free radicals and of the antioxidant defence.
Biochemical studies may contribute to the understanding of OCD and its
treatment.

Keywords: Antioxidants; Free radicals; Malondialdehyde;
Obsessive-compulsive disorder; Vitamin C; Vitamin E

Abbreviations: DTSC, dinitrophenolhydrazine-thiourea-copper sulphate;
GSH-Px, glutathione peroxidase; MDA, malondialdehyde; OCD,
obsessive-compulsive disorder; SOD, superoxide dismutase; TPTZ,
2,4,6-tripridil-s-triazine

Corresponding author. C.U. Hastanesi Psikiyatri ABD, 58140 Sivas,
Turkey. Tel./fax: +90 346 2191574.

Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume 30, Issue 6 , 30 August 2006, Pages 1039-1042

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Sir Arthur C.B.E. Wholefl · medicine forum beginner Joined: 03 Jul 2006 Posts: 1

This parallels the work that my laboratory is working on! Interesting
stuff, to say the least!

ironjustice@aol.com wrote:

outsor@citynet.net · medicine forum Guru Joined: 11 Sep 2005 Posts: 569

This is one of the most ironic postings one could ever imagine, think
about it a minute. Oxygen is the cause of all disease.

monty1945@lycos.com · medicine forum addict Joined: 02 Apr 2006 Posts: 93

Do some searches for oxidative stress or lipid peroxidation - a huge
number of people are working on this, but the mainstream media hardly
ever reports it, an never on the main players, such as arachidonic acid
metabolites.

Sumbuny · medicine forum beginner Joined: 03 Jul 2006 Posts: 1

<outsor@citynet.net> wrote in message
news:44a932ae$0$76287$4d5ecec7@reader.city-net.com...

Google