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ironjustice@aol.com
medicine forum Guru
Joined: 28 Apr 2005
Posts: 1522
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 Posted: Tue Jun 27, 2006 11:29 am Post subject:
Green tea extract bifunctional natural iron chelator
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Iron-chelating and free-radical scavenging activities of
microwave-processed green tea in iron overload.
Srichairatanakool S, Ounjaijean S, Thephinlap C, Khansuwan U,
Phisalpong C, Fucharoen S
Hemoglobin. 2006; 30(2): 311-27
Secondary iron overload is found in beta-thalassemia (thal) patients
because of increased dietary iron absorption and multiple blood
transfusions. Excessive iron catalyzes free-radical generation, leading
to oxidative damage and vital organ dysfunction. Non-transferrin-bound
iron (NTBI) detected in thalassemic plasma is highly toxic and
chelatable. Though used to treat iron overload, desferrioxamine (DFO)
and deferiprone (L1) also have adverse effects. Green tea (GT) shows
many pharmacological effects, particularly antioxidative and
iron-chelating capacities. This study was performed to investigate the
ability of GT extracts to reduce plasma NTBI concentration and
oxidative stress in vitro. The Fe3+ was found to bind to GT crude
extract and form a complex. Green tea crude extract time- and
dose-dependently decreased plasma NTBI concentration and counteracted
the increase of oxidative stress in both Fe 2+-EDTA-treated human
plasma and erythrocytes. Green tea is a bifunctional natural product
that could be relevant for management of iron overload and oxidative
stress.
Abstract · PubMed FullText · SFX · GS Clip Export InterDB ·
Terms Related · Graph Cites · Scopus · Tag
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
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DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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outsor@citynet.net
medicine forum Guru
Joined: 11 Sep 2005
Posts: 569
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| Posted: Tue Jun 27, 2006 12:39 pm Post subject:
Re: Green tea extract bifunctional natural iron chelator
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Another example of a rare genetic blood disorder causing iron overload,
not relevant to most people. Does not support iron causes all disease
because people eat meat notion, another dog and tail thing. |
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Sylv
medicine forum addict
Joined: 27 Aug 2005
Posts: 86
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| Posted: Tue Jun 27, 2006 3:54 pm Post subject:
Re: Green tea extract bifunctional natural iron chelator
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outsor@citynet.net wrote:
| Quote: | Another example of a rare genetic blood disorder causing iron overload,
not relevant to most people. Does not support iron causes all disease
because people eat meat notion, another dog and tail thing.
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And some of us do NOT eat meat of any kind and still manage to get
diseases.
Ironjustice is dead wrong. . .but anyone with any brains who has read
his rants already knows this.
Sylvia (who also drinks green tea) |
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NHE
medicine forum beginner
Joined: 04 Jun 2006
Posts: 2
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| Posted: Wed Jun 28, 2006 10:26 am Post subject:
Re: Green tea extract bifunctional natural iron chelator
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"ironjustice@aol.com" wrote:
| Quote: |
Iron-chelating and free-radical scavenging activities of
microwave-processed green tea in iron overload.
Srichairatanakool S, Ounjaijean S, Thephinlap C, Khansuwan U,
Phisalpong C, Fucharoen S
Hemoglobin. 2006; 30(2): 311-27
Secondary iron overload is found in beta-thalassemia (thal) patients
because of increased dietary iron absorption and multiple blood
transfusions. Excessive iron catalyzes free-radical generation, leading
to oxidative damage and vital organ dysfunction. Non-transferrin-bound
iron (NTBI) detected in thalassemic plasma is highly toxic and
chelatable. Though used to treat iron overload, desferrioxamine (DFO)
and deferiprone (L1) also have adverse effects. Green tea (GT) shows
many pharmacological effects, particularly antioxidative and
iron-chelating capacities. This study was performed to investigate the
ability of GT extracts to reduce plasma NTBI concentration and
oxidative stress in vitro. The Fe3+ was found to bind to GT crude
extract and form a complex. Green tea crude extract time- and
dose-dependently decreased plasma NTBI concentration and counteracted
the increase of oxidative stress in both Fe 2+-EDTA-treated human
plasma and erythrocytes. Green tea is a bifunctional natural product
that could be relevant for management of iron overload and oxidative
stress.
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What may be more interesting about green tea and MS is that the antioxidant
epigallocatechin gallate (EGCG) found in green tea inhibits the
transcription factor NF-kB which produces proinflammatory cytokines.
NHE |
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