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An American paradox - sat fat & coronary arteries
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Jim Chinnis
medicine forum Guru


Joined: 30 Apr 2005
Posts: 1030

PostPosted: Tue Jun 27, 2006 5:31 pm    Post subject: Re: An American paradox - sat fat & coronary arteries Reply with quote

"Juhana Harju" <shantigiriorama@gmail.com> wrote in part:

Quote:
Jim Chinnis wrote:
: "Juhana Harju" <shantigiriorama@gmail.com> wrote in part:
:: coronary wrote:
::
::: An American paradox - sat fat & coronary arteries
::: http://www.ajcn.org/cgi/content/full/80/5/1102 Saturated fat
::: prevents coronary
::: artery disease? An American paradox1,2 Robert H Knopp
::
:: The great weakness of that editorial by Knopp and Retzlaff is that
:: they are suggesting a very dubious way of increasing HDL -
:: increasing saturated fats. There are many practical ways to increase
:: HDL that are known to be healthy and so there is absolutely no sense
:: in increasing saturated fat.
:
: I don't see any weakness in that at all. I do see great weakness in
: the research they discuss, however. The conclusion from the abstract
: of the study described in the editorial is:
:
: "Conclusions: In postmenopausal women with relatively low total fat
: intake, a greater saturated fat intake is associated with less
: progression of coronary atherosclerosis, whereas carbohydrate intake
: is associated with a greater progression."

It is typical of low-carb proponents to cherry-pick studies to support their
position. Finding some exceptions or paradoxes does not change the fact that
weight of evidence is still against saturated fat.

: Again though, this is an observational study, with all the
: deficiencies that implies.
:
: The 1954 study mentioned in the editorial would be interesting to
: read. At least it was a randomized trial of moderate duration. Does
: anyone know how to find a copy on the web?
:
: The ref:
:
: Lancet. 1972 Oct 21;2(7782):835-8.
:
: Effect of cholesterol-lowering diet on mortality from coronary
: heart-disease and other causes. A twelve-year clinical trial in men
: and women.
:
: Miettinen M, Turpeinen O, Karvonen MJ, Elosuo R, Paavilainen E.

The above study is mentioned often. I tried to find it, but it seems that it
is not available online.

I seem to have located a hard copy, along with hard copies of the other
(old) studies that seem to form the basis for the "saturated fat causes
heart disease" mantra. I should have them in about ten days from university
libraries.
--
Jim Chinnis Warrenton, Virginia, USA jchinnis@alum.mit.edu
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Jim Chinnis
medicine forum Guru


Joined: 30 Apr 2005
Posts: 1030

PostPosted: Tue Jun 27, 2006 5:35 pm    Post subject: Re: An American paradox - sat fat & coronary arteries Reply with quote

Jim Chinnis <jchinnis@alum.mit.edu> wrote in part:

Quote:
"Juhana Harju" <shantigiriorama@gmail.com> wrote in part:

Jim Chinnis wrote:
: "Juhana Harju" <shantigiriorama@gmail.com> wrote in part:
:: coronary wrote:
::
::: An American paradox - sat fat & coronary arteries
::: http://www.ajcn.org/cgi/content/full/80/5/1102 Saturated fat
::: prevents coronary
::: artery disease? An American paradox1,2 Robert H Knopp
::
:: The great weakness of that editorial by Knopp and Retzlaff is that
:: they are suggesting a very dubious way of increasing HDL -
:: increasing saturated fats. There are many practical ways to increase
:: HDL that are known to be healthy and so there is absolutely no sense
:: in increasing saturated fat.
:
: I don't see any weakness in that at all. I do see great weakness in
: the research they discuss, however. The conclusion from the abstract
: of the study described in the editorial is:
:
: "Conclusions: In postmenopausal women with relatively low total fat
: intake, a greater saturated fat intake is associated with less
: progression of coronary atherosclerosis, whereas carbohydrate intake
: is associated with a greater progression."

It is typical of low-carb proponents to cherry-pick studies to support their
position. Finding some exceptions or paradoxes does not change the fact that
weight of evidence is still against saturated fat.

: Again though, this is an observational study, with all the
: deficiencies that implies.
:
: The 1954 study mentioned in the editorial would be interesting to
: read. At least it was a randomized trial of moderate duration. Does
: anyone know how to find a copy on the web?
:
: The ref:
:
: Lancet. 1972 Oct 21;2(7782):835-8.
:
: Effect of cholesterol-lowering diet on mortality from coronary
: heart-disease and other causes. A twelve-year clinical trial in men
: and women.
:
: Miettinen M, Turpeinen O, Karvonen MJ, Elosuo R, Paavilainen E.

The above study is mentioned often. I tried to find it, but it seems that it
is not available online.

I seem to have located a hard copy, along with hard copies of the other
(old) studies that seem to form the basis for the "saturated fat causes
heart disease" mantra. I should have them in about ten days from university
libraries.

The main papers I'm talking about are:

Kinsell LW, Michaels GD, Cochrane GC, Partridge JW, Jahn JP, Balch HE.
Effect of vegetable fat on hypercholesterolemia and hyperphospholipidemia:
observations on diabetic and nondiabetic subjects given diets high in
vegetable fat and protein. Diabetes 1954;3:113-9.

Miettinen M, Turpeinen O, Karvonen MJ, Elosuo R, Paavilainen E. Effect of
cholesterol-lowering diet on mortality from coronary heart-disease and other
causes. A twelve-year clinical trial in men and women. Lancet 1972;2:835-8.
--
Jim Chinnis Warrenton, Virginia, USA jchinnis@alum.mit.edu
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