is ospA dead, or is ospA dead?

eugeneshapiroisapig · medicine forum Guru Joined: 24 Mar 2005 Posts: 2108

J Peripher Nerv Syst. 2004 Sep;9(3):165-7. Related Articles, Links
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Neuropathy and cognitive impairment following vaccination with the
OspA protein of Borrelia burgdorferi.

Latov N, Wu AT, Chin RL, Sander HW, Alaedini A, Brannagan TH 3rd.

Department of Neurology and Neurosciences, Weill Medical College of
Cornell University, New York, NY 10022, USA. nol2002@med.cornell.edu

Neurological syndromes that follow vaccination or infection are
often attributed to autoimmune mechanisms. We report six patients who
developed neuropathy or cognitive impairment, within several days to 2
months, following vaccination with the OspA antigen of Borrelia
burgdorferi. Two of the patients developed cognitive impairment, one
chronic inflammatory demyelinating polyneuropathy (CIDP), one
multifocal motor neuropathy, one both cognitive impairment and CIDP,
and one cognitive impairment and sensory axonal neuropathy. The
patients with cognitive impairment had T2 hyperintense white matter
lesions on magnetic resonance imaging. The similarity between the
neurological sequelae observed in the OspA-vaccinated patients and
those with chronic Lyme disease suggests a possible role for immune
mechanisms in some of the manifestations of chronic Lyme disease that
are resistant to antibiotic treatment.

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