eugeneshapiroisapig
medicine forum Guru
Joined: 24 Mar 2005
Posts: 2108
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 Posted: Sat Jun 24, 2006 5:34 pm Post subject:
Another interesting article
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J Neuroimmunol. 2005 Feb;159(1-2):192-5. Epub 2004 Nov 26. Related
Articles, Links
Click here to read Click here to read
Antibodies against OspA epitopes of Borrelia burgdorferi
cross-react with neural tissue.
Alaedini A, Latov N.
Department of Neurology and Neuroscience, Cornell University, 1300
York Ave., New York, NY 10021, USA. ara2004@med.cornell.edu
Neurological sequela of chronic Lyme disease include
encephalopathy, myelopathy and peripheral neuropathy. These have
generally been attributed to either persistent infection or
pathogen-induced autoimmunity. In this study, we investigated the
presence of cross-reactive human neural epitopes that share amino acid
sequences with Borrelia burgdorferi OspA protein. Sequence similarity
analysis was carried out by searching known cDNA sequences from brain
tissue. The cDNA database search yielded three sequences that were
identical to sequences in OspA. Corresponding peptides were synthesized
and antibodies were generated against them in rabbits. Antibodies
against two of the homologous OspA peptides were found to react with
neurons in human brain, spinal cord and dorsal root ganglia by
immunohistochemistry. |
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