Can It be a reason for getting addiction/dependance etc.?

Kumar · medicine forum Guru Joined: 10 May 2005 Posts: 870

Hello,

Since my thread "Can nutrients be addictive" is derailed, I am
refresing and restructuring the subject here.

""Local blood flow control can be divided into two phases;

1)Acute - rapid change constriction/dilatation of arteriols,
metarteriol et spincters.

2)Long-term control provides a better control by increasing/decreasing
the physical size and number of blood vessels supplying the tissues. "

""From "Text book of Medical physiology by Guyton & Hall

"Long term regulation of blood flow is esp. important when metabolic
demands of tissue change. Thus, if a tisue become chronicallt
overactive and therefore require chronicaly increased quantity of
oxygen and other nutrients, the blood vessels usually increase within
few weeks almost to match needs of the the tissues--unless the
circulatory system has become pathological too old to repond.

The mechanism of long term local blood flow regulation is principally
to change the degree of vascularity of the tissues. For instance; if
metabolism in in a given tissue is increased for a prolonged time
vascularity increases; if the metabolism is decreased, vascularity
decreases. Thus there is reconstruction of the tissue vasculature to
meet the needs of the tissues. The reconstruction occurs rapidly(within
days)
in exteremely young animals. It also occurs rapidly in new growth
tissue, such as scar tissue and cancerous tissue; however it occurs
much more slowly in old, well established tissues.

Oxygen is important not only for acute but also long term control of
local blood flow. One example of this in to increase in vascularity in
the tissues of animals that live on high altitudes, where the
atmospheric oxygen is low. A second example is that fetel chicks
hatched in low oxygen have upto twice as muchblood vessel conductivity
as is normally true. This same effect is also dramatically demonstrated

in premature human babies who are put on oxygen tents for therapeutic
purposes. The excess O2 causes almost immediate cesstion of new
vascular growth in the retina of the premature baby's eyes and even
causes degenaration of some of the capillaries that already have
formed. Then when the infant is taken out of the o2 tent, there is
explosive overgroth of new vessels to make up for the sudden decrease
in available oxygen; indeed, there is often so much overgroth that
vessels grow into the eye's vitreous humor and eventuall cause
blindness. (This condition is called "retrolental fibroplasia"). ""

In consideration of above, I want to understand:-

Can excesses/accumulation or defficiencies of six nutrients esp.carbs,
fats and protiens trigger and establish long term local blood flow
control of increasing/decreasing
the physical size and number of blood vessels supplying the
tissues--due to gap in supply and demand?

If yes, Can it be considered as addiction, physical dependance,
physiological tolerance etc. and will reversing of such excesses of
nutrients show some "withdraw symptoms"?

Can such establishment of long term local blood flow regulation of
"increasing/decreasing the physical size and number of blood vessels
supplying the tissues" be considered as a reason to getting addictions,
dependances or tolerances with possible withdrawl symptoms which may be
due to reversing of established local blood flow regulation?

Best wishes.

Dennis R. · medicine forum beginner Joined: 24 Jun 2006 Posts: 1

In article <1151136952.300046.81300@i40g2000cwc.googlegroups.com>,
lordshiva5753@rediffmail.com says...

Kumar · medicine forum Guru Joined: 10 May 2005 Posts: 870

Dennis R. wrote:

Rob · medicine forum beginner Joined: 06 Mar 2006 Posts: 33

In message <1151197248.191221.268760@p79g2000cwp.googlegroups.com>,
kumar <lordshiva5753@rediffmail.com> writes

Kumar · medicine forum Guru Joined: 10 May 2005 Posts: 870

Rob wrote:

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