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Forum index » diseases » cancer
Remission in Mouse
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Barbara Harris
medicine forum beginner


Joined: 11 Sep 2005
Posts: 5

PostPosted: Fri Jun 16, 2006 2:38 pm    Post subject: Remission in Mouse Reply with quote
If a substance provides tumor remission/ and or inhibition at a rate of 2
milligrams per week per lab rat, what extrapolated
rate would be appropriate for 70 kg adult?
Would it be 140 milligrams per week? Or is it more complicated than a
straight linear shift?

Thanks
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Steph
medicine forum Guru


Joined: 03 May 2005
Posts: 504

PostPosted: Sat Jun 17, 2006 3:01 am    Post subject: Re: Remission in Mouse Reply with quote
"JACK HARRIS" <beeh2003@yahoo.com> wrote in message
news:Enzkg.60232$4L1.59017@newssvr11.news.prodigy.com...
Quote:
If a substance provides tumor remission/ and or inhibition at a rate of 2
milligrams per week per lab rat, what extrapolated
rate would be appropriate for 70 kg adult?
Would it be 140 milligrams per week? Or is it more complicated than a
straight linear shift?

Thanks



Well, if it was a 1kg rat, I guess a straight linear computation would give
you 140 mg.
But that's a big rat............

And doses are usually calculated on body surface area, which is a bit of a
more complex calculation.

Assuming, of course that the effects and metabolism of the drug are the same
in man and rat..........
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